The MICs of fusidic acid and two sulphonamides for nine strains of , two strains of and one strain of were studied by means of a plate-dilution technique. The median value for the MIC of fusidic acid, 2·5 fig per ml, compared very favourably with those of the sulphonamides, and fusidic acid may well have a part to play in the treatment of nocardiosis.

We would like to acknowledge the generous supply of fusidic acid by Leo Laboratories Limited, sulphadiazine by May & Baker Limited and sulphamethoxazole by the Wellcome Foundation. We are also very grateful to those mentioned in the text who supplied us with strains of . Finally we wish to thank Dr J. C. J. Ives for helpful criticisms and advice.


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