1887

Abstract

SUMMARY

The MICs of fusidic acid and two sulphonamides for nine strains of , two strains of and one strain of were studied by means of a plate-dilution technique. The median value for the MIC of fusidic acid, 2.5 fig per ml, compared very favourably with those of the sulphonamides, and fusidic acid may well have a part to play in the treatment of nocardiosis.

We would like to acknowledge the generous supply of fusidic acid by Leo Laboratories Limited, sulphadiazine by May & Baker Limited and sulphamethoxazole by the Wellcome Foundation. We are also very grateful to those mentioned in the text who supplied us with strains of . Finally we wish to thank Dr J. C. J. Ives for helpful criticisms and advice.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-4-2-293
1971-05-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jmm/4/2/medmicro-4-2-293.html?itemId=/content/journal/jmm/10.1099/00222615-4-2-293&mimeType=html&fmt=ahah

References

  1. Baikie A. G., Macdonald C. B., Mundy G. R. 1970; Systemic nocardiosis treated with trimethoprim and sulphamethoxazole. Lancet 2:261
    [Google Scholar]
  2. Black W. A., McNellis Dora A. 1970; Sensitivity of Nocardia to trimethoprim and sulphonamides in-vitro . J. Clin. Path 23:423
    [Google Scholar]
  3. Garrod L. P., O’Grady F. 1968 Antibiotic and chemotherapy 2nd ed Edinburgh:
    [Google Scholar]
  4. Hierholzer G., Knothe H., Rehn J., Koch F. 1966; Fusidinsaure-Konzentrationen in chronisch entziindetem Gewebe. Untersuchungen zur chronischen posttraumatischen Osteomyelitis. Arzneimittel-Forsch 16:1549
    [Google Scholar]
  5. Hoeprich P. D., Brandt D., Parker R. H. 1968; Nocardial brain abscess cured with cycloserine and sulfonamides. Amer. J. Med. Sci 255:208
    [Google Scholar]
  6. Neu H. C., Silva M., Hazen E., Rosenheim S. H. 1967; Necrotizing nocardial pneumonitis. Ann. Intern. Med 66:274
    [Google Scholar]
  7. Peabody J. W. Jr, Seabury J. H. 1960; Actinomycosis and nocardiosis. A review of basic differences in therapy. Amer. J. Med 28:99
    [Google Scholar]
  8. Shuster M., Klein M. M., Pribor H. C., Kozub W. 1967; Brain abscess due to Nocardia. Report of a case. Archs Intern. Med 120:610
    [Google Scholar]
  9. Stewart G. T. 1964; Steroid antibiotics. Pharmakotherapia 2:137
    [Google Scholar]
  10. Stokes E. Joan. 1968 Clinical bacteriology 3rd ed London: p 176
    [Google Scholar]
  11. Vasarinsh P. 1968; Primary cutaneous nocardiosis. Archs Derm 98:489
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-4-2-293
Loading
/content/journal/jmm/10.1099/00222615-4-2-293
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error