1887

Abstract

Summary

A chloroform-soluble, extracellular product of was obtained from sloppy-agar cultures. Pyrogallol 1-monomethyl ether, 1-methoxyphenazine, 1-hydroxyphenazine and pyocyanin were chemically synthesised and also tested for an inhibitory effect on mitochondrial respiration. It was found that the substance and 1-hydroxyphenazine inhibited the uptake of oxygen by mouse liver mitochondria utilising sodium succinate.

In a infection this substance would be released into the bloodstream, accumulate in the liver and cause cytolysis, thus contributing to the complex mechanism of pathogenicity.

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/content/journal/jmm/10.1099/00222615-4-2-249
1971-05-01
2019-10-22
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-4-2-249
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