Attempts were made to induce a carrier state in Swiss mice by intranasal inoculation of . A high mortality rate (90 per cent.) was observed when organisms were instilled intranasally, Aerosol infection also produced a high mortality (50 per cent.) and a rather low over-all carrier rate (30 per cent). When the organism was directly implanted with mild trauma (multiple puncture) on the nasal mucosa the mortality rate was reduced to 20 per cent. and nearly half of the initial animal population became nasal carriers of . A significant number (54·8 per cent.) of 685 mice treated by the multiple puncture method developed a delayed type of hypersensitivity to the test staphylococcus and the sensitisation effect was most evident among the carrier animals.


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