Several extracts prepared by the action of surface active agents on live cells of the rough strain 45/20 were found to protect mice and guinea-pigs against challenge with virulent . Incorporation in oily emulsions made little difference to the degree of immunity elicited.

An extract prepared by treatment of living cells of strain 45/20 with sodium dodecy1 sulphate followed by ethanol precipitation induced substantial immunity in cattle, despite the fact that no adjuvant was used. The extract was devoid of the smooth O somatic antigen and probably free from lipopoly-saccharide. The high protein and carbohydrate content suggested that the immunogen could be a glycoprotein.


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