Sera were tested for capsular antibody and for bactericidal factor against Haemophilus influenzae type b. The age-distribution of the bactericidal factor corresponded to the known age-distribution of immunity to serious infection with H. influenzae type b, but that of the capsular antibody did not. This finding argues against the belief that the protective antibody to H. influenzae type-b infections is that produced against its capsular antigen.
AlexanderHattie E.1965; The Hemophilus group. In Bacterial and mycotic infections of man 4th ed., edited by
DubosR. J.,
HirschJ. G.
London: ch. 29, p 724
FothergillL. D.,
WrightJ.1933; Influenzal meningitis: the relation of age incidence to the bactericidal power of blood against the causal organism. J. Immun 24:273
MacLeodC. M.,
BernheimerA. W.1965; Pathogenic properties of bacteria. In Bacterial and mycotic infections of man 4th ed., edited by
DubosR. J.,
HirschJ. G.
London: ch. 7, p 146