1887

Abstract

SUMMARY

A highly toxic fraction causing dermonecrosis in guinea-pigs and a lethal effect in mice was obtained from phase-1 organisms. Intravenous injection of this toxic fraction into mice produced a considerable reduction in spleen weight within 7 days. The histological findings indicate that causes an atrophy of the spleen. The term “lienotoxicity” is proposed to designate this toxic phenomenon. Whether dermonecrosis, lethality and lienotoxicity are caused by three different agents contained in the preparation studied has not been determined.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-4-1-51
1971-02-01
2024-10-06
Loading full text...

Full text loading...

/deliver/fulltext/jmm/4/1/medmicro-4-1-51.html?itemId=/content/journal/jmm/10.1099/00222615-4-1-51&mimeType=html&fmt=ahah

References

  1. Andersen Else K. 1957; Studies on the occurrence of lung oedema in mice after intranasal H. pertussis inoculation. Acta path, microbiol. scand 40:248
    [Google Scholar]
  2. Bradford W. L. 1938; Experimental infection in the mouse produced by intratracheal inoculation with Hemophilus pertussis. Amer. J. Path 14:377
    [Google Scholar]
  3. Burnet F. M., Timmins Cecily. 1937; Experimental infection with Haemophilus pertussis in the mouse by intranasal inoculation. Br. J. Exp. Path 18:83
    [Google Scholar]
  4. Dougherty T. F., White A. 1945; Functional alterations in lymphoid tissue induced by adrenal cortical secretion. Amer. J. Anat 77:81
    [Google Scholar]
  5. Ehrich W. E., Bondi A. Jr, Mudd S., Flosdorf E. W. 1942; The tolerance of rabbits for the agglutinogen and the toxins of Hemophilus pertussis. Amer. J. Med. Sci 204:530
    [Google Scholar]
  6. Ishida S. 1968; Characterization of the body weight-decreasing toxicities in mice by the lymphocytosis-promoting factor and the heat-labile toxin of B. pertussis and endotoxin. Jap. J. Med. Sci. Biol 21:115
    [Google Scholar]
  7. Iwasa S., Asakawa S., Ishida S., Kurokawa M. 1966; The study on lymphocytosis-promoting factor produced by Bordetella pertussis. Jap. J. Bact 22:233 (in Japanese)
    [Google Scholar]
  8. Iwasa S., Ishida S., Asakawa S., Kurokawa M. 1968; Lymphocytosis-promoting factor produced by Bordetella pertussis. Partial purification and characterization. Jap. J. Med. Sci. Biol 21:363
    [Google Scholar]
  9. Kurokochi T. 1961; Studies on pertussal toxin. VIII. The histopathological studies on each organ of mice inoculated with pertussal toxin. Jap. J. Bact 16:1046 (in Japanese)
    [Google Scholar]
  10. Meister A. 1952; Crystalline lactate dehydrogenase. In Biochemical preparations ed. by Ball E. G. New York: vol 2: p 18
    [Google Scholar]
  11. Morse S. I. 1964; Studies on the leukocytosis induced by Bordetella pertussis. J. Pediat 65:1019
    [Google Scholar]
  12. Morse S. I. 1965; Studies on the lymphocytosis induced in mice by Bordetella pertussis. J. Exp. Med 121:49
    [Google Scholar]
  13. Morse S. I. 1966; The effect of hydrocortisone and X-irradiation on the lymphocytosis induced by Bordetella pertussis. J. Exp. Med 123:283
    [Google Scholar]
  14. Morse S. I., Bray Karen K. 1969; The occurrence and properties of leukocytosis and lymphocytosis-stimulating material in the supernatant fluids of Bordetella pertussis cultures. J. Exp. Med 129:523
    [Google Scholar]
  15. Morse S. I., Riester Sallie K. 1967a; Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. I. Radioautographic analysis of the circulating cells in mice undergoing pertussis-induced hyperleukocytosis. J. Exp. Med 125:401
    [Google Scholar]
  16. Morse S. I., Riester Sallie K. 1967b; Studies on the leukocytosis and lymphocytosis induced by Bordetella pertussis. II. The effect of pertussis vaccine on the thoracic duct lymph and lymphocytes of mice. J. Exp. Med 125:619
    [Google Scholar]
  17. Onoue K., Kitagawa M., Yamamura Y. 1963; Chemical studies on cellular components of Bordetella pertussis. III. Isolation of highly potent toxin from Bordetella pertussis. J. Bact 86:648
    [Google Scholar]
  18. Sato M. 1958; Studies on the fractionation of Haemophilus pertussis antitoxin. Jap. J. Microbiol 2:279
    [Google Scholar]
  19. Sato M., Tenjin H., Iida T. 1958; Fractionation of Haemophilus pertussis antiserum proteins. Jap. J. Microbiol 2:309
    [Google Scholar]
  20. Taguchi M. 1958; Studies on a variant of Bordetella pertussis. Jap. J. Bact 13:966 (in Japanese)
    [Google Scholar]
  21. Yamamoto A., Iida T., Komatsu N., Ogata S., Komase Y., Sato M., Yoshida T. 1959; Studies on the pertussal toxin. II. Nisshin Igaku 46:384 (in Japanese)
    [Google Scholar]
/content/journal/jmm/10.1099/00222615-4-1-51
Loading
/content/journal/jmm/10.1099/00222615-4-1-51
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error