1887

Abstract

SUMMARY

It has been suggested that the bactericidal antibody associated with immunity to acute primary infections is that produced against the capsular antigen of type b. In a previous study, however, the bactericidal and the type-b capsular antibodies were found to have different age-distributions. In the present studies the age-distributions of children with bactericidal antibody and of those with agglutinins against non-capsulated strains were found to be similar. Furthermore, it was possible to absorb type-b bactericidins from rabbit antisera with non-capsulated strains without removing the type-b capsular antibody. These findings, together with other evidence in the literature, suggest that the antigen responsible for the production of the bactericidal antibody is somatic and is possessed by non-capsulated strains, although attempts to produce type-b bactericidins in rabbits immunised with these non-capsulated strains were unsuccessful.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-4-1-43
1971-02-01
2024-04-25
Loading full text...

Full text loading...

/deliver/fulltext/jmm/4/1/medmicro-4-1-43.html?itemId=/content/journal/jmm/10.1099/00222615-4-1-43&mimeType=html&fmt=ahah

References

  1. Dingle J. H., Fothergill L. D., Chandler Caroline A. 1938; Studies on Haemophilus influenzae; III. The failure of complement of some animal species, notably the guinea pig, to activate the bactericidal function of sera of certain other species. J. Immun 34:357
    [Google Scholar]
  2. Dubos R. J. 1942; A soluble toxin produced by Hemophilus influenzae. J. Bact 43:77
    [Google Scholar]
  3. Fothergill L. D., Wright J. 1933; Influenzal meningitis: the relation of age incidence to the bactericidal power of blood against the causal organism. J. Immun 24:273
    [Google Scholar]
  4. Leidy G., Hahn E., Zamenhof S., Alexander H. E. 1960; Biochemical aspects of virulence of Hemophilus influenzae. Ann. N. Y. Acad. Sci 88:1195
    [Google Scholar]
  5. MacPherson Catherine F. C. 1948; A method of typing Haemophilus influenzae by the precipitin reaction. Canad. J. Res Ser. E 26:197
    [Google Scholar]
  6. Mathies A. W., Hodgman J., Ivler D. 1965; Hemophilus influenzae meningitis in a premature infant. Pediatrics, Springfield 35:791
    [Google Scholar]
  7. May J. R. 1965; Haemophilus influenzae antigen-antibody reactions. J. Path. Bact 90:379
    [Google Scholar]
  8. Mpairwe Y. 1970; Observations on the nasopharyngeal carriage of Haemophilus influenzae type b in children in Kampala, Uganda. J. Hyg., Camb 68:337
    [Google Scholar]
  9. Mpairwe Y. 1971; Immunity to Haemophilus influenzae type b: the role of the capsular antibody. J. Med. Microbiol 4:85
    [Google Scholar]
  10. Pittman Margaret. 1931; Variation and type specificity in the bacterial species Haemophilus influenzae. J. Exp. Med 53:471
    [Google Scholar]
  11. Pittman Margaret. 1933; The action of type-specific Haemophilus influenzae antiserum. J. Exp. Med 58:683
    [Google Scholar]
  12. Raffel S. 1953 Immunity, hypersensitivity, serology New York: ch. 19
    [Google Scholar]
  13. Smith M. H. D. 1956; Acute bacterial meningitis. Pediatrics, Springfield 17:258
    [Google Scholar]
  14. Tunevall G. 1953; Studies on Haemophilus influenzae: a complement fixation test for Haemophilus influenzae antibody. Acta path, microbiol. scand 32:258
    [Google Scholar]
  15. Turk D. C. 1963; Naso-pharyngeal carriage of Haemophilus influenzae type B. J. Hyg., Camb 61:247
    [Google Scholar]
  16. Turk D. C., Green C. A. 1964; Measurement of antibodies reacting with capsular antigens of Haemophilus influenzae. J. Clin. Path 17:294
    [Google Scholar]
  17. Turk D. C., May J. R. 1967; ‘Haemophilus influenzae’, its clinical importance. London
    [Google Scholar]
  18. Wright J., Ward H. K. 1932; Studies on influenzal meningitis: II. B. influenzae— the problem of virulence and resistance. J. Exp. Med 55:235
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-4-1-43
Loading
/content/journal/jmm/10.1099/00222615-4-1-43
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error