1887

Abstract

Summary

High-level mupirocin resistance in coagulase-negative staphylococci isolated from patients undergoing peritoneal dialysis was investigated by transfer of the resistance determinants, usually in the form of a plasmid, to strains, cleavage of the plasmid by restriction endonuclease and hybridisation with a probe comprising a 4.05 kb R1 fragment of a plasmid from a strain. In most instances the mupirocin-resistant staphylococci isolated from each patient were different according to the species, antibiogram and plasmid profile data. The mupirocin resistance determinant was carried on various plasmids as judged by R1 restriction fragment length polymorphisms. All hybridised at about 4 kb with the probe.

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1993-12-01
2023-02-01
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