1887

Abstract

Summary

The purpose of this study was to clarify the association between the oral infectivity of a bacterial strain and its susceptibility to ingestion by mononuclear phagocytes or ability to survive within them. Ten bacterial strains tested—all of known oral infectivity—comprised (three strains), (two strains), and a sp. The phagocytic uptake of each strain was measured as the bacteria to phagocyte ratio after mononuclear phagocytes in mouse peritoneal exudate were permitted to ingest bacteria for 3 min. The three strains were the most susceptible to phagocytic uptake and the strain was relatively resistant. The intracellular survival of each strain was studied during a subsequent 2 h in-vitro incubation of the mononuclear phagocytes that had been permitted to ingest bacteria The strains with the best intracellular survival were and two of the three strains. The ability of to survive intracellularly was intermediate but better than that of the two strains. Oral infectivity was not consistently correlated with susceptibility to ingestion by mononuclear phagocytes or ability to survive within them.

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/content/journal/jmm/10.1099/00222615-38-5-345
1993-05-01
2020-01-20
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