Strains of sp., sp. and all produced inhibitors of β-adrenergic receptor binding; strains of sp. and sp. did not. In tests with glutamic acid as the sole nutrient source, a sp. produced four-fold larger amounts of inhibitor than the other fungi. The inhibitor from the sp. was further purified by lyophilisation and sequential solvent extractinon in chloroform, ethyl acetate and butanol; 60% of the original activity was recovered. The inhibitor had an estimated molecular size of 650 Da, and did not absorb light in the visible or ultraviolet range. When compared with a similar inhibitor from , the sp. inhibitor appeared to be a more potent inhibitor of β-adrenergic and dopaminergic binding to mammalian cells.


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