1887

Abstract

Summary

Strains of sp., sp. and all produced inhibitors of β-adrenergic receptor binding; strains of sp. and sp. did not. In tests with glutamic acid as the sole nutrient source, a sp. produced four-fold larger amounts of inhibitor than the other fungi. The inhibitor from the sp. was further purified by lyophilisation and sequential solvent extractinon in chloroform, ethyl acetate and butanol; 60% of the original activity was recovered. The inhibitor had an estimated molecular size of 650 Da, and did not absorb light in the visible or ultraviolet range. When compared with a similar inhibitor from , the sp. inhibitor appeared to be a more potent inhibitor of β-adrenergic and dopaminergic binding to mammalian cells.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-38-1-44
1993-01-01
2019-10-24
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-38-1-44
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error