1887

Abstract

Summary

Intragastric inoculation with hepatotoxigenic strains of led to the death of mice during the late phase of infection. Histological study disclosed a massive infiltration of mononuclear cells in the liver, mimicking intrahepatic hypersensitivity. Neither enterotoxigenic nor enteroinvasive induced such a lesion. However, the same histopathological change was induced by injecting the hepatotoxic factor of hepatotoxigenic intravenously on two occasions separated by 14 days. Neither a single injection of an increased dose of the hepatotoxic factor nor two injections, the second of which was heat-inactivated, induced this change. Pre-treatment with rabbit antibody to the hepatotoxic factor inhibited the development of the hepatic lesion. These results suggest that -induced hepatic lesions in mice may be caused, at least in part, by the active moiety of the hepatotoxic factor. The possible mechanisms by which the toxic factor induces hepatitis as a consequence of hypersensitivity are discussed in relation to Guillain-Barré syndrome and Reiter’s syndrome associated with enteritis.

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1992-11-01
2024-03-28
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References

  1. Ruiz-Palacios G. M., Torres J., Torres N. I., Escamilla E., Ruiz-Palacios B. R., Tamayo J. Cholera-like enterotoxin produced by Campylobacter jejuni. Lancet 1983; 2:250–253
    [Google Scholar]
  2. Blaser M. J., Berkowitz I. D., LaForce F. M., Cravens J., Reller L. B., Wang W.-L. L-Campylobacter enteritis: clinical and epidemiologic features. Ann Intern Med 1979; 91:179–185
    [Google Scholar]
  3. Klipstein F. A., Engert R. F. Properties of crude Campylobacter jejuni heat-labile enterotoxin. Infect Immun 1984; 45:314–319
    [Google Scholar]
  4. Lambert M. E., Schofield P. F., Ironside A. G., Mandal B. K. Campyl obacter colitis. BMJ 1979; 1:857–859
    [Google Scholar]
  5. Drake A. A., Gilchrist M. J. R., Washington J. A., Huizenga K. A., Van Scoy R. E. Diarrhea due to Campylobacter fetus subspecies jejuni. A clinical review of 63 cases. Mayo Clin Proc 1981; 56:414–423
    [Google Scholar]
  6. Ruiz-Palacios G. M., Escamilla E., Torres N. Experimental Campylobacter diarrhea in chickens. Infect Immun 1981; 34:250–255
    [Google Scholar]
  7. Ampelas M., Perez C., Jourdan J. Hepatite a Campylobacter coli. Nouv Press Med 1982; 11:593–595 (English abstract)
    [Google Scholar]
  8. Reddy K. R., Thomas E. Campylobacter jejuni enterocolitis and hepatitis. Gastroenterology 1982; 82:1156 (Abstract)
    [Google Scholar]
  9. Pitkanen T., Ponka A., Pettersson T., Kosunen T. U. Campylo bacter enteritis in 188 hospitalized patients. Arch Intern Med 1983; 143:215–219
    [Google Scholar]
  10. Kita E., Katsui N., Nishi K., Emoto M., Yanagase Y., Kashiba S. Hepatic lesions in experimental Campylobacter jejuni infection of mice. J Gen Microbiol 1986; 132:3095–3103
    [Google Scholar]
  11. Kita E., Oku D., Hamuro A. Hepatotoxic activity of Campylobacter jejuni. J Med Microbiol 1990; 33:171–182
    [Google Scholar]
  12. Yamai S., Obara Y., Nikkawa T., Shimoda Y., Miyamoto Y. Preservation of Neisseria gonorrhoeae by the gelatin-disc method. Br J Vener Dis 1979; 55:90–93
    [Google Scholar]
  13. Skirrow M. B. Campylobacter enteritis: A “new” disease. BMJ 1977; 2:9–11
    [Google Scholar]
  14. Reed L. J., Muench H. Simple method of estimating 50 percent endpoints. Am J Hyg 1938; 27:493–497
    [Google Scholar]
  15. Kiehlbauch J. A., Albach R. A., Baum L. L., Chang K. -P. Phago-cytosis of Campylobacter jejuni and its intracellular survival in mononuclear phagocytes. Infect Immun 1985; 48:446–451
    [Google Scholar]
  16. Hsu H. S. Pathogenesis and immunity in murine salmonellosis. Microbiol Rev 1989; 53:390–409
    [Google Scholar]
  17. Keith B., Taylor M. D., Howard C. Gastrointestinal and liver diseases. In Stites D. P. et al. (eds) Basic and clinical immunology 5th edn California: Lange Medical Publications; 1984520–543
    [Google Scholar]
  18. Paronen I. Reiter’s disease: study of 344 cases observed in Finland. Acta Med Scand Suppl 212 1948; 131:1–114
    [Google Scholar]
  19. Noer H. R. An “experitnental” epidemic of Reiter’s syndrome. JAMA 1966; 198:693–698
    [Google Scholar]
  20. Berglof F. E. Arthritis and intestinal infection. Acta Rheumatol Scand 1963; 9:141–149
    [Google Scholar]
  21. Vartiainen J., Hurri L. Arthritis due to Salmonella typhimurium. Report of 12 cases of migratory arthritis in association with Salmonella typhimurium infection. Acta Med Scand 1984; 175:771–776
    [Google Scholar]
  22. Warren C. P. W. Arthritis associated with salmonella infections. Ann Rheum Dis 1970; 29:483–487
    [Google Scholar]
  23. Ahvonen P., Sievers K., Aho K. Arthritis associated with Yersinia enterocolitica infection. Acta Rheumatol Scand 1969; 15:232–253
    [Google Scholar]
  24. Ahvonen P. Human yersiniosis in Finland. II. Clinical features. Ann Clin Res 1972; 4:39–48
    [Google Scholar]
  25. Aho K., Ahvonen P., Lassus A., Sievers K., Tiilikainen A. HL-A27 in reactive arthritis. A study of yersinia arthritis and Reiter’s disease. Arth Rheum 1974; 17:521–526
    [Google Scholar]
  26. Berden J. H. M., Muytjens H. L., van de Putte L. B. A. Reactive arthritis associated with Campylobacter jejuni enteritis. BMJ 1979; 1:380–381
    [Google Scholar]
  27. Yuki N., Yoshino H., Sato S., Miyatake T. Acute axonal polyneuropathy associated with anti-GM antibodies following Campylobacter enteritis. Neurology 1990; 40:1900–1902
    [Google Scholar]
  28. Begue P., Broussin B., Carros I., Vu-Thien H. Campylobacter intestinal infection. Med Mai Infect 1989; 19:48–54
    [Google Scholar]
  29. Canton P., Hoen B., Gerard A., May T., Burdin P. Infections due to Campylobacter non-digestive manifestations. Med Mai Infect 1989; 19:43–47
    [Google Scholar]
  30. Clavelou P., Beytout J., Gourdiat A., Garandeau A., Deffond D., Tournilhac M. Atteintes neurologiques au décours d’in fections à Campylobacter. Cinq cas. Rev Neurol 1989; 145:208–214 (English abstract)
    [Google Scholar]
  31. Frampton G., Winer J. B., Cameron J. S., Hughes R. A. C. Severe Guillain-Barré syndrome: an association with IgA anti-cardiolipin antibody in a series of 92 patients. J Neuro-immunol 1988; 19:133–139
    [Google Scholar]
  32. Winer J. B., Hughes R. A. C., Anderson M. J., Jones D. M., Kangro H., Watkins R. P. F. A prospective study of acute idiopathic neuropathy. II. Antecedent events. J Neurol Neurosurg Psychiatry 1988; 51:613–618
    [Google Scholar]
  33. Ropper A. H. Campylobacter diarrhea and Guillain-Barre syndrome. Arch Neurol 1988; 45:655–656
    [Google Scholar]
  34. Wuthe H. H., Erichsen H. Specificity of antibodies against common antigens of Campylobacter jejuni/coli tested by immunoblotting. Arztl Lab 1987; 33:304–306
    [Google Scholar]
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