Thirty-five isolates, 21 isolates and four strains of were compared for their ability to agglutinate red blood cells (RBCs). Isolates were examined in a slide haemagglutination assay with RBCs from 11 animal species, including rodents, carnivores and primates, as well as man. RBCs were agglutinated by 65–90% of isolates and 16–57% of isolates. Treatment of with pronase and heat inhibited haemagglutination (HA) whereas heating only of inhibited HA. Treatment of all strains of with trypsin inhibited agglutination of human RBCs; 75% of the treated strains did not agglutinate ferret RBCs. These results suggested that protein(s) may be important haemagglutinins for these bacteria. Variable HA profiles together with varying results after treatment of RBCs with fetuin, D-mannose, and neuraminidase suggested that multiple receptors may be involved in HA reactions with and The observation that and agglutinated RBCs of several species and closely adhered to gastric epithelium supported the hypothesis that adherence plays a role in the colonisation and pathogenicity of and did not adhere to gastric epithelium and did not agglutinate RBCs of any species; nevertheless, can readily colonise and produce gastritis in several mammals.


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