1887

Abstract

Summary

Protection against experimental infection in mice was enhanced by prior injection of formalin-killed or viable bacteria of the same strain. From the first to the fourth week after vaccination, specific immunity was involved in the host defence against systemic serratia infection. The transfer of antiserum specific for increased bacterial clearance from the liver, but did not increase the survival of the mice. Bacterial clearance from the liver was also increased by the transfer of spleen cells from immunised mice, but, again, survival was not increased. However, the transfer of both antiserum and spleen cells from vaccinated mice increased both bacterial clearance from the liver and survival (p <0.01). These results suggest an additive effect of humoral immunity and T-cell-mediated immunity in protection against systemic serratia infection.

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1992-04-01
2024-12-07
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References

  1. Maki D. G., Hennekens C. G., Phillips C. W., Shaw W. V., Bennett J. V. Nosocomial urinary tract infection with Serratia marcescens: an epidemiologic study. J Infect Dis 1973; 128:579–587
    [Google Scholar]
  2. Balikian J. P., Herman P. G., Godleski J. J. Serratia pneumonia. Radiology 1980; 137:309–311
    [Google Scholar]
  3. Bosch J. A., Vilaseca M., Fernandez F. Sepsis caused by Serratia marcescens. Report of 19 cases. Rev Clin Esp 1979; 155:93–96
    [Google Scholar]
  4. Sautter R. L., Mattman L. H., Legaspi R. C. Serratia marcescens meningitis associated with a contaminated benzalkonium chloride solution. Infect Control 1984; 5:223–225
    [Google Scholar]
  5. Kumagai Y., Okada K., Ishimaru T., Sawae Y., Kuroiwa A., Nomoto K. Effects of vaccination against systemic Serratia infection. J Clin Lab Immunol 1989; 29:125–132
    [Google Scholar]
  6. Simberkoff M. S., Moldover N. H., Rahal J. J. Specific and nonspecific immunity to Serratia marcescens infection. J Infect Dis 1976; 134:348–353
    [Google Scholar]
  7. Tsuda S., Sasai Y., Minami K., Nomoto K. Contribution of T cell-mediated immunity to the resistance to staphylococcal infection. J Invest Dermatol 1978; 70:345–347
    [Google Scholar]
  8. Akeda H., Mitsuyama M., Tatsukawa K., Nomoto K., Takeya K. The synergistic contribution of macrophages and antibody to protection against Salmonella typhimurium during the early phase of infection. J Gen Microbiol 1981; 123:209–214
    [Google Scholar]
  9. Finney D. J. Probit analysis. A statistical treatment of the sigmoid response curve. Cambridge: Cambridge University Press; 1952
    [Google Scholar]
  10. Hahn H., Kaufmann S. H. E. The role of cell-mediated immunity in bacterial infections. Rev Infect Dis 1981; 3:1221–1250
    [Google Scholar]
  11. Klastersky J. Infections in immuno-compromised patients. I. Pathogenesis, etiology, and diagnosis. Clin Ther 1985; 8:90–99
    [Google Scholar]
  12. Carter P. B. Pathogenicity of Yersinia enterocolitica for mice. Infect Immun 1975; 11:164–170
    [Google Scholar]
  13. Horwitz M. A., Silverstein S. C. Legionnaires’ disease bacterium (Legionellapneumophila) multiplies intracellularly in human monocytes. J Clin Invest 1980; 66:441–450
    [Google Scholar]
  14. World Health Organization Scientific Group Cell-mediated immunity and resistance to infection. WHO Technical Report Series 1973; 519:6–64
    [Google Scholar]
  15. Zinkernagel R. M. Review: Cellular immune responses to intracellular parasites: role of the major histocompatibility gene complex and thymus in determining immune responsiveness and susceptibility to disease. Parasite Immunol 1979; 1:91–109
    [Google Scholar]
  16. Fukutome T., Mitsuyama M., Takeya K., Nomoto K. Importance of antiserum and phagocytic cells in the protection of mice against infection by Klebsiella pneumoniae. J Gen Microbiol 1980; 119:225–229
    [Google Scholar]
  17. Ogata N. Analysis of protective mechanisms against infection by Pseudomonas aeruginosa: the synergistic contribution of polymorphonuclear leucocytes and antibody. Fukuoka Igaku Zasshi 1983; 74:335–350 (in Japanese)
    [Google Scholar]
  18. Tsuru S., Nomoto K., Mitsuyama M., Zinnaka Y., Takeya K. Importance of polymorphonuclear leucocytes in protection of mice against Escherichia coli. J Gen Microbiol 1981; 122:335–338
    [Google Scholar]
  19. Keam R. J., Hinrichs D. J. Kinetics and maintenance of acquired resistance in mice to Listeria monocytogenes. Infect Immun 1977; 16:923–927
    [Google Scholar]
  20. Lane F. C., Unanue E. R. Requirement of thymus (T) lymphocytes for resistance to listeriosis. J Exp Med 1972; 135:1104–1112
    [Google Scholar]
  21. Mackaness G. B. The influence of immunologically committed lymphoid cells on macrophage activity in vivo. J Exp Med 1969; 129:973–992
    [Google Scholar]
  22. Mitsuyama M., Nomoto K., Akeda H., Takeya K. Enhanced elimination of Listeria monocytogenes at the site of delayed foot-pad reaction. Infect Immun 1980; 30:1–4
    [Google Scholar]
  23. Hobson D. Resistance to reinfection in experimental mouse typhoid. JHyg 1957; 55:334–343
    [Google Scholar]
  24. Holland J. J., Pickett M. J. A cellular basis of immunity in experimental Brucella infection. J Exp Med 1958; 108:343–360
    [Google Scholar]
  25. Mackaness G. B. Cellular resistance to infection. J Exp Med 1962; 116:381–406
    [Google Scholar]
  26. Stableforth A. W. Brucellosis. In Stableforth A. W., Galloway I. A. (eds) Infectious disease of animals vol 1 London: Butterworths Scientific Publications; 195953–159
    [Google Scholar]
  27. Carney J. M., Wame M. S., Borut T. Cell-mediated immune defects and infection. Am J Dis Child 1980; 134:824–827
    [Google Scholar]
  28. George C. D., Morello P. J. Immunologic effects of blood transfusion upon renal transplantation, tumor operations, and bacterial infections. Am J Surg 1986; 152:329–337
    [Google Scholar]
  29. Clumeck N., George C. Immunological aspects of severe bacterial sepsis. Intensive Care Med 1981; 7:109–114
    [Google Scholar]
  30. Miedema F., Tetteroo P. A. T., Terpstra F. G. Immunologic studies with LFA-1- and Mol-deficient lymphocytes from a patient with recurrent bacterial infections. J Immunol 1985; 134:3075–3081
    [Google Scholar]
  31. Petersen P. K. Host defense abnormalities predisposing the patient to infection. Am J Med 1984; 76(5A):2–10
    [Google Scholar]
  32. Sorensen R. U., Stern R. C., Chase P., Polmar S. H. Defective cellular immunity to gram-negative bacteria in cystic fibrosis patients. Infect Immun 1979; 23:398–402
    [Google Scholar]
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