Induction by the 4-quinolone group of antibacterial drugs of the gene, the SOS function most involved in error-prone DNA repair (together with ), was assessed in a strain of harbouring a gene fusion. All 4-quinolones tested induced this fusion, with maximum induction at 4-quinolone concentrations close to their minimum inhibitory concentrations for this strain, and the SOS Inducing Potential (SOSIP) was closely related to antibacterial activity. Mitomycin C, a known mutagen, was a slightly better inducer (in terms of SOSIP) than any of the quinolones. In contrast, induction by 4-quinolones of the () gene, an SOS function involved in cell division inhibition, was better than induction by mitomycin C in an strain harbouring an gene fusion. The gene fusion was induced at lower concentrations of 4-quinolone than was the gene fusion.


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