1887

Abstract

Summary

The function of peritoneal macrophages induced by intraperitoneal (i.p.) injection of attenuated (OK-432), Bacillus Calmette Guérin (BCG), protein-bound polysaccharide preparation isolated from (PSK) or was examined. The PMA-triggered respiratory burst (production of O and HO) of macrophages induced by OK-432, BCG or was greater than that of resident or thioglycollate-stimulated macrophages and was similar to that of BCG-activated macrophages. PSK failed to enhance the production of O or HO by macrophages. Alkaline phosphodiesterase (APD) activity was reduced in macrophages induced by OK-432, BCG or injection and in BCG-activated macrophages. The APD activity of macrophages obtained 7 and 13 days after i.p. injection of PSK was elevated, as with thioglycollate-stimulated macrophages. Listericidal activity was enhanced in macrophages obtained in 13 and 7 days, but suppressed in macrophages obtained 2 days after OK-432, BCG or injection. administered either 2 or 13 days before infection with was protective but OK-432, BCG (0.1 mg) and PSK were not, even though they were able to stimulate macrophage function.

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/content/journal/jmm/10.1099/00222615-36-2-112
1992-02-01
2023-01-28
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References

  1. Aoki T., Kvedar J. P., Hollis V. W., Bushar G. S. Streptococcus pyogenes preparation OK-432: immunoprophylactic and immunotherapeutic effects on the incidence of spontaneous leukemia in AKR mice. J Natl Cancer Inst 1976; 56:687–690
    [Google Scholar]
  2. Lagrange P. H., Gheorghiu M. Antitumor activity of two BCG vaccine preparations against the Lewis lung carcinoma in mice. Cancer Immunol Immunother 1981; 11:217–224
    [Google Scholar]
  3. Ohno R., Imai K., Yokomaku S., Yamada K. Antitumor effect of protein bound polysaccharide preparation, PS-K, against 3 methylcholanthrene induced fibrosarcoma in C57BL/6 mice. Gann 1975; 66:679–681
    [Google Scholar]
  4. Saito H., Watanabe T., Tomioka H., Sato K., Kitagawa T. Enhanced resistance to Pseudomonas aeruginosa infection in mice pretreated with OK-432. Hiroshima J Med Sci 1983; 32:235–239
    [Google Scholar]
  5. Weintraub J., Weinbaum F. I. The effect of BCG on experimental cutaneous leishmaniasis in mice. J Immunol 1977; 118:2288–2290
    [Google Scholar]
  6. Saito H., Tomioka H., Nagashima K. Protective and therapeutic efficacy of Lactobacillus casei against experimental murine infections due to Mycobacterium fortuitum complex. J Gen Microbiol 1987; 133:2843–2861
    [Google Scholar]
  7. Sato K. Enhancement of host resistance against Listeria infection by Lactobacillus casei: role of macrophages. Infect Immun 1984; 44:445–451
    [Google Scholar]
  8. Watanabe T., Saito H. Protection of mice against herpes simplex virus infection by a Lactobacillus casei preparation (LC 9018) in combination with inactivated viral antigen. Microbiol Immunol 1986; 30:111–122
    [Google Scholar]
  9. Kato I., Kobayashi S., Yokokura T., Mutai M. Antitumor activity of Lactobacillus casei in mice. Gann 1981; 72:517–523
    [Google Scholar]
  10. Sato K., Saito H., Tomioka H. Enhancement of host resistance against Listeria infection by Lactobacillus casei: activation of liver macrophages and peritoneal macrophages by Lactobacillus casei. Microbiol Immunol 1988; 32:689–698
    [Google Scholar]
  11. Efthymiou C., Hanson P. A. An antigenic analysis of Lactobacillus acidophilus. J Infect Dis 1962; 110:258–267
    [Google Scholar]
  12. Johnston R. B., Godzik C. A., Cohn Z. A. Increased superoxide anion production by immunologically activated and chemically elicited macrophages. J Exp Med 1978; 148:115–127
    [Google Scholar]
  13. Tomioka H., Saito H. Hydrogen peroxide-releasing function of chemically elicited and immunologically activated macrophages: differential response to wheat germ lectin and concanavalin A. Infect Immun 1980; 29:469–476
    [Google Scholar]
  14. Edelson P. J., Erbs C. Plasma membrane localization and metabolism of alkaline phosphodiesterase I in mouse peritoneal macrophages. J Exp Med 1978; 147:77–86
    [Google Scholar]
  15. Morahan P. S., Edelson P. J., Gass K. Changes in macrophage ecotoenzymes associated with anti-tumor activity. J Immunol 1980; 125:1312–1317
    [Google Scholar]
  16. Nathan C. F., Root R. K. Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering. J Exp Med 1977; 146:1448–1662
    [Google Scholar]
  17. Mitsuyama M., Takeya K., Nomoto K., Shimotori S. Three phases of phagocyte contribution to resistance against Listeria monocytogenes. J Gen Microbiol 1978; 106:165–171
    [Google Scholar]
  18. Newborg M. F., North R. J. On the mechanism of T cell-independent anti-Listeria resistance in nude mice. J Immunol 1980; 124:571–576
    [Google Scholar]
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