1887

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Volume 36, Issue 1

Comparison of Clostridium sordellii toxins HT and LT with toxins A and B of C. difficile Free

Abstract

Summary

Clostridium sordellii produces two toxins, designated HT (haemorrhagic toxin) and LT (lethal toxin), that are similar to toxins A and B of The physicochemical properties of toxins HT and A were remarkably similar. The specific biological activities of toxin HT were almost the same as those of toxin A, and their NH-terminal sequences shared close homology. The properties of toxins LT and B were similar, as were their NH-terminal sequences, but toxin B was much more cytotoxic than toxin LT. Immunodiffusion analysis with specific antibodies showed that although toxins B and LT shared major antigenic determinants, each had unique epitopes. The results suggest that toxins B and LT have diverged more than toxins A and HT. Immunoblotting with antibodies to the toxins of showed that toxins HT and LT had common antigenic determinants.

  • Received:
  • Accepted:
  • Published Online:
© J. MED. MICROBIOL. 1986
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1992-01-01
2024-04-23
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Comparison of Clostridium sordellii toxins HT and LT with toxins A and B of C. difficile
J. Med. Microbiol. 36, 30 (1992); https://doi.org/10.1099/00222615-36-1-30
/content/journal/jmm/10.1099/00222615-36-1-30
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