%0 Journal Article %A Odell, E. W. %A Segal, A. W. %T Killing of pathogens associated with chronic granulomatous disease by the non-oxidative microbicidal mechanisms of human neutrophils %D 1991 %J Journal of Medical Microbiology, %V 34 %N 3 %P 129-135 %@ 1473-5644 %R https://doi.org/10.1099/00222615-34-3-129 %I Microbiology Society, %X Summary The susceptibility of opportunist pathogens associated with chronic granulomatous disease (CGD) to the non-oxidative killing mechanisms of neutrophils has been assessed by incubation in human neutrophil primary granule lysate. The dose and pH-dependency of killing of Aspergillus fumigatus, Candida albicans, Escherichia coli, Nocardia asteroides, Serratia marcescens and Staphylococcus aureus differed markedly and may partly explain their virulence in CGD, in which oxygen-dependent killing mechanisms are defective. At the acid pH in CGD neutrophil phagosomes S. aureus, Ser. marcescens, N. asteroides and A. fumigatus spores were highly resistant but C. albicans a less frequent pathogen in patients with CGD, was much more susceptible. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-34-3-129