@article{mbs:/content/journal/jmm/10.1099/00222615-34-3-129, author = "Odell, E. W. and Segal, A. W.", title = "Killing of pathogens associated with chronic granulomatous disease by the non-oxidative microbicidal mechanisms of human neutrophils", journal= "Journal of Medical Microbiology", year = "1991", volume = "34", number = "3", pages = "129-135", doi = "https://doi.org/10.1099/00222615-34-3-129", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-34-3-129", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "Summary The susceptibility of opportunist pathogens associated with chronic granulomatous disease (CGD) to the non-oxidative killing mechanisms of neutrophils has been assessed by incubation in human neutrophil primary granule lysate. The dose and pH-dependency of killing of Aspergillus fumigatus, Candida albicans, Escherichia coli, Nocardia asteroides, Serratia marcescens and Staphylococcus aureus differed markedly and may partly explain their virulence in CGD, in which oxygen-dependent killing mechanisms are defective. At the acid pH in CGD neutrophil phagosomes S. aureus, Ser. marcescens, N. asteroides and A. fumigatus spores were highly resistant but C. albicans a less frequent pathogen in patients with CGD, was much more susceptible.", }