1887

Abstract

Summary

The susceptibility of opportunist pathogens associated with chronic granulomatous disease (CGD) to the non-oxidative killing mechanisms of neutrophils has been assessed by incubation in human neutrophil primary granule lysate. The dose and pH-dependency of killing of and differed markedly and may partly explain their virulence in CGD, in which oxygen-dependent killing mechanisms are defective. At the acid pH in CGD neutrophil phagosomes and spores were highly resistant but a less frequent pathogen in patients with CGD, was much more susceptible.

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1991-03-01
2022-12-01
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