1887

Abstract

Ciprofloxacin, unlike nalidixic acid, can kill cells in the absence of synthesis of protein of RNA. Hence, chloramphenicol or rifampicin do not abolish the bactericidal activity of ciprofloxacin against wild-type . Protein and RNA synthesis were not required for the bactericidal activity of ciprofloxacin against and mutants of . However, the addition of chloramphenicol or rifampicin abolished the bactericidal activity of ciprofloxacin against a mutant in nutrient broth. It is concluded that the ability of ciprofloxacin to kill in the absence of protein or RNA synthesis involves the A subunit of DNA gyrase.

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/content/journal/jmm/10.1099/00222615-34-1-19
1991-01-01
2019-12-10
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-34-1-19
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