1887

Abstract

Summary

Since patients with AIDS may receive fluoroquinolones concurrently with zidovudine, the antibacterial interaction of these drugs was investigated. No evidence was found of antagonism between zidovudine and ciprofloxacin, DR-3355, enoxacin, lomefloxacin or ofloxacin against enterobacteria, staphylococci or . Furthermore, the bactericidal activity of the fluoroquinolones against selected enterobacteria in nutrient broth was not affected by a clinically achievable concentration of zidovudine. It seems unlikely that zidovudine will have an adverse effect on the antibacterial activity of the fluoroquinolones in patients with AIDS.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-33-2-127
1990-10-01
2024-12-13
Loading full text...

Full text loading...

/deliver/fulltext/jmm/33/2/medmicro-33-2-127.html?itemId=/content/journal/jmm/10.1099/00222615-33-2-127&mimeType=html&fmt=ahah

References

  1. Hirsch M S. AIDS commentary. Azidothymidine. J Infect Dis 1988; 157:427–431
    [Google Scholar]
  2. Mitsuya H, Broder S. Strategies for antiviral therapy in AIDS. Nature 1987; 325:773–778
    [Google Scholar]
  3. Yarchoan R, Klecker RW, Weinhold KJ et al. Administra tion of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex. Lancet 1986; 1:575–580
    [Google Scholar]
  4. Elwell L, Ferone R, Freeman GA et al. Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U). Antimicrob Agents Chemother 1987; 31:274–280
    [Google Scholar]
  5. Lewin CS, Amyes SGB. Conditions required for the antibacterial activity of zidovudine. Eur J Clin Microbiol 1989; 8:737–741
    [Google Scholar]
  6. Keith BR, White G, Wilson HR. In vivo efficacy of zidovudine (3'-azido-3'-deoxythymidine) in experimental gram-negative-bacterial infections. Antimicrob Agents Chemother 1989; 33:479–483
    [Google Scholar]
  7. Smith JT, Lewin CS. Chemistry and mechanisms of action of the quinolone antibacterials. In: Andriole VT. (ed) The quinolones London: Academic Press; 19882382
    [Google Scholar]
  8. Andriole VT. Clinical overview of newer 4-quinolone antibacterial agents. In: Andriole VT. (ed) The quinolones London: Academic Press; 1988155–200
    [Google Scholar]
  9. Bogner T, Goebel FD. Recurrent salmonella bacteriaemia in a patient with acquired immunodeficiency syndrome. AIDS Forschung 1986; 1:669–671
    [Google Scholar]
  10. Young LS. Treatable aspects of infection due to acquired immunodeficiency virus. Lancet 1987; 2:1503–1506
    [Google Scholar]
  11. Rolston KV, Rodriguez S, Mansell PWA. Antimicrobial therapy for salmonella infections in acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1988; 108:309
    [Google Scholar]
  12. Jacobson MA, Hahn SM, Geberding JL, Lee B, Sande MA. Ciprofloxacin for salmonella bacteremia in the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 1989; 110:1027–1029
    [Google Scholar]
  13. Sande MA. Antimicrobial therapy of infections in patients with AIDS—an overview. J Antimicrob Chemother 1989; 23:Suppl A63–65
    [Google Scholar]
  14. Lewin CS, Smith JT. Interactions of the 4-quinolones with other antibacterials. J Med Microbiol 1989; 29:221–227
    [Google Scholar]
  15. Smith JT. Awakening the slumbering potential of the 4-quinolone antibacterials. Pharm J 1984; 233:299–305
    [Google Scholar]
  16. Lewin CS, Amyes SGB. The bactericidal activity of DR-3355, an optically active isomer of ofloxacin. J Med Microbiol 1989; 30:227–231
    [Google Scholar]
  17. Lewin CS, Howard BMA, Ratcliffe NT, Smith JT. 4-quinolones and the SOS response. J Med Microbiol 1989; 29:139–144
    [Google Scholar]
/content/journal/jmm/10.1099/00222615-33-2-127
Loading
/content/journal/jmm/10.1099/00222615-33-2-127
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error