1887

Abstract

Summary

A marked increase in the prevalence of bacteraemia due to of serogroup O 15 was noted during November and December 1986 at Charing Cross Hospital. This multiresistant strain had been reported by several hospitals in south London. All isolates of from patients with bacteraemia between October 1986 and the end of September 1988 were assessed for the presence of the O 15 antigen and for the unusual pattern of resistance to six antimicrobial agents. As a guide to faecal carriage, isolates from urine were similarly assessed during seven 4-week periods between January 1987 and June 1988. Of the 123 isolates from blood, 25 (20%) were serogroup O 15 and 20 of these expressed the same pattern of multiresistance; 17 of these multiresistant isolates occurred in the 4-month period 1 Nov. 1986-28 Feb. 1987. During the remaining 19 months of the study only eight isolates were serogroup O 15 of which only three were multiresistant. In the first 4-week period that urine isolates were studied 21 Jan. 1987-17 Feb. 1987, 26 (13-2%) of the 195 isolates were serogroup O 15 of which 20 were multiresistant. The proportion of serogroup O 15 isolates fell gradually until, in June 1988, the last period studied, only 8 (4.2%) of the 189 isolates were serogroup O 15 of which only one was multiresistant. In a preliminary study of plasmids in six serogroup O 15 isolates from blood, three multiresistant isolates and one that was sensitive to chloramphenicol appeared to carry a similar plasmid of 100 Mda. A strain that expressed the multiresistance pattern except for tetracycline sensitivity carried four plasmids, the largest of which was 70 Mda. No plasmids were found in the one fully sensitive strain studied.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-33-1-23
1990-09-01
2023-01-29
Loading full text...

Full text loading...

/deliver/fulltext/jmm/33/1/medmicro-33-1-23.html?itemId=/content/journal/jmm/10.1099/00222615-33-1-23&mimeType=html&fmt=ahah

References

  1. Eykyn S, Phillips I. Community outbreak of multiresistant invasive Escherichia coli infection. Lancet 1986; 2:1454
    [Google Scholar]
  2. Grune berg RN, Leigh DA, Brumfitt W. Escherichia coli serotypes in urinary tract infections: studies in domiciliary, antenatal and hospital practice. In: O’Grady F, Brumfitt W. (eds) Urinary tract infection London: Oxford University Press; 196868–79
    [Google Scholar]
  3. Cowan ST. Cowan and Steel’s Manual for the identification of medical bacteria. , 2nd edn.. Cambridge: Cambridge University Press; 1974
    [Google Scholar]
  4. Roberts AP, Linton JD, Waterman AM, Gower PE, Koutsaimanis KG. Urinary and faecal Escherichia coli O-serogroups in symptomatic urinary-tract infection and asymptomatic bacteriuria. J Med Microbiol 1975; 8:311–318
    [Google Scholar]
  5. Kado Cl, Liu ST. Rapid procedure for detection and isolation of large and small plasmids. J. Bacteriol 1981; 145:1365–1373
    [Google Scholar]
  6. Devine DA, Robinson L, Roberts AP. Occurrence of K1, K5 and O-antigens in Escherichia coli isolates from patients with urinary tract infections or bacteraemia. J Med Microbiol 1989; 30:295–299
    [Google Scholar]
  7. Wright ED, Perinpanayagam RM. Multiresistant invasive Escherichia coli infection in south London. Lancet 1987; 1:556–557
    [Google Scholar]
  8. Waghorn DJ, Kelly TWJ, Gibbins W. Epidemic multires istant Escherichia coli infection in south London. J Hosp Infect 1988; 11:192–193
    [Google Scholar]
  9. Reeves DS, Bailey RA, Bywater MJ, Holt HA, MacGowan AP, Marshall RJ. Failure to detect multiresistant Escherichia coli in Bristol. Lancet 1987; 1:929
    [Google Scholar]
  10. Roberts AP, Phillips R. Bacteria causing symptomatic urinary tract infection or asymptomatic bacteriuria. J Clin Pathol 1979; 32:492–496
    [Google Scholar]
  11. Hughes C, Bauer E, Roberts AP. Spread of R-plasmids among Escherichia coli causing urinary tract infections. Antimicrob Agents Chemother 1981; 20:496–502
    [Google Scholar]
  12. Roberts AP, Hughes C. Relation of O-serotypes with resistance to antibiotics. Chemioterapia 19854 Suppl 2:12–14
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-33-1-23
Loading
/content/journal/jmm/10.1099/00222615-33-1-23
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error