The growth of nine species of colonic bacteria— and —was examined after concomitant injection to form experimental subcutaneous abscesses in mice. Injection of a mixture of c. 10 cfu of each of the first five strains ( and ) resulted in abscess formation in all mice tested when the strain was haemolytic. and multiplied and reached a maximum population of c. 10 cfu/abscess. When non-haemolytic was used, injection of ≥10 cfu was required for abscess formation. The inclusion of partially purified haemolysin (125 HU ) with c. 10 cfu of bacteria including non-haemolytic resulted in abscess formation in most mice tested. These results indicate that haemolysin is one factor that may potentiate pathogenic synergy among colonic bacteria especially between and during abscess formation.


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