1887

Abstract

The conditions required to kill with nalidixic acid, ciprofloxacin, norfloxacin or ofloxacin were determined in nutrient broth and in phosphate-buffered saline. They were found to be similar to the conditions required for these 4-quinolones to kill Bacterial RNA synthesis and bacterial cell division were essential for the bactericidal activity of nalidixic acid but all three fluoroquinolones were bactericidal against non-dividing However, as with , bacterial RNA synthesis was essential for the bactericidal activity of norfloxacin though this was not required to kill with ciprofloxacin or ofloxacin.

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1990-07-01
2022-08-08
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References

  1. Deitz W H., Cook T M., Goss W A. Mechanism of action of nalidixic acid on Escherichia coli III. Conditions required for lethality. J Bacterial 1966; 91:768–773
    [Google Scholar]
  2. Smith J T. Awakening the slumbering potential of the 4-quinolone antibiotics. Pharm J 1984; 233:299–305
    [Google Scholar]
  3. Smith J T., Lewin C S. Chemistry and mechanisms of action of the quinolone antibacterials. In Andriole V. ed The quinolones. London: Academic Press; 198823–82
    [Google Scholar]
  4. Lewin C S., Amyes S G B. The bactericidal activity of DR-3355, an optically active isomer of ofloxacin. J Med Microbiol 1989; 30:227–231
    [Google Scholar]
  5. Lewin C S., Amyes S G B., Smith J T. Bactericidal activity of enoxacin and lomefloxacin against Escherichia coli KL16. EurJ Clin Microbiol Infect Dis 1989; 8:731–733
    [Google Scholar]
  6. Lewin C S., Amyes S G B. Conditions required for the bactericidal activity of pefloxacin and fleroxacin against Escherichia coli KL16. J Med Microbiol 1990; 32:83–86
    [Google Scholar]
  7. Zeiler H-J., Grohe K. The in-vitro and in-vivo activity of ciprofloxacin. Eur J Clin Microbiol 1984; 3:339–343
    [Google Scholar]
  8. Ratcliffe N T., Smith J T. Norfloxacin has a novel bactericidal mechanism unrelated to that of other 4-quinolones. J Pharm Pharmacol 1985; 37:92
    [Google Scholar]
  9. Smith J T. Frequency and expression of mutational resist ance to the 4-quinolone antibacterials. Scand J Infect Dis 1986; 49:suppl115–123
    [Google Scholar]
  10. Lewin C S., Allen R A., Amyes S G B. Potential mechanisms of resistance to the modem fluorinated 4-quinolones. J Med Microbiol 1990; 31:153–161
    [Google Scholar]
  11. Watanabe M., Inoue M., Mitsuhashi S. In vitro activity of amifloxacin against outer membrane mutants of the family enterobacteriaceae and frequency of sponta-neous resistance. Antimicrob Agents Chemother 1989; 33:1837–1840
    [Google Scholar]
  12. Smith J T. In-vitro and in-vivo mutation frequencies to resistance. Do they correlate in the long term?. In Crumplin G C. ed 4-quinolone antibacterial agents in vitro . Heidelberg: Springer Verlag; In press
    [Google Scholar]
  13. Schacht P., Hullman R. Changes of susceptibility of infecting organisms to ciprofloxacin during treatment. Abstracts of the Congress on Bacterial and Parasitic Drug Resistance, Bangkok; 1986109
    [Google Scholar]
  14. Suzuki K., Nagata Y., Naide Y., Horiba M. Clinical study of strains of Pseudomonas aeruginosa and Serratia marces-cens resistant to new quinolones in complicated urinary tract infection. Rev Infect Dis 1989; 11:Suppl 5S969–S970
    [Google Scholar]
  15. Lewin C S., Howard B M A., Ratcliffe N T., Smith J T. 4-quinolones and the SOS response. J Med Microbiol 1989; 29:139–144
    [Google Scholar]
  16. Lewin C S., Smith J T. Bactericidal mechanisms of ofloxacin. J Antimicrob Chemother 1988; 22:Suppl. C1–8
    [Google Scholar]
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