A model was developed in mice to study the pathogenesis of urinary tract infections caused by strains LM-1 and LM-2, SP444 and E001. Murine urinary bladders were inoculated with 108 bacteria a temporary urinary catheter and samples of urine and bladder were removed at days 1, 3, 5 and 10 after inoculation. They were examined both bacteriologically and by electronmicroscopy. Severe disruption of the urothelium was present immediately and the urothelium had become oedematous and ulcerated with increased urothelial exfoliation. Disruption of the urothelium was similar with all the four pathogens studied. The three strains of coagulase-negative staphylococci preferentially attached to the urothelial cell tight junctions and were not associated with polymorphonuclear leucocytes. In comparison, SP444 was randomly attached over the entire urothelium and was often in association with macrophages. Phagocytosis of by superficial urothelial cells also occurred.


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