1887

Abstract

Summary

An enzyme linked immunosorbent assay (ELISA) with a sonicated suspension of as antigen was used to detect anti- antibodies in 517 patients without dyspepsia or peptic ulcer symptoms and 401 healthy blood donors. The criterion of seropositivity was determined from a receiver operating curve computed with the values of optical densities of 48 sera from dyspeptic patients with proven helicobacter-associated gastritis and 16 sera from dyspeptic patients with proven helicobacter-associated gastritis and 16 sera from dyspeptic patients with normal antral mucosa and no microbiological or histological evidence of infection. The 227 (44%) seropositive persons amongst the patient group appeared to be significantly higher than the 142 (35%) sera with antibodies in the blood donors tested (p<0·03), even when adjustment was made for increasing age. We conclude that the prevalence of antibodies against increases with age and that although antibodies are more prevalent in patients attending a hospital than in healthy blood donors, seropositivity suggestive of current or past infection can be found in one third of a randomly chosen population of blood donors.

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1990-06-01
2024-04-18
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References

  1. Marshall B J., Warren J R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984; 1:1311–1315
    [Google Scholar]
  2. Graham D Y., Klein P D. Campylobacter pyloridis gastritis: the past, the present and speculations about the future. Am J Gastroenterol 1987; 82:283–286
    [Google Scholar]
  3. Price A B., Levi J., Dolby J M. et al. Campylobacter pyloridis in peptic ulcer disease: microbiology, pathology and scanning electron microscopy. Gut 1985; 26:1183–1188
    [Google Scholar]
  4. Axon A T R. Campylobacter pyloridis: what role in gastritis and peptic ulcer?. Br Med J 1986; 293:772–773
    [Google Scholar]
  5. Rathbone B J., Wyatt J I., Heatley R V. Campylobacter pyloridis, a new factor in peptic ulcer disease ?. Gut 1986; 27:635–641
    [Google Scholar]
  6. Kreuning J., Bosman F T., Kuiper G., Wal A M v.d., Lindeman J. Gastric and duodenal mucosa in healthy individuals. J Clin Pathol 1978; 31:69–77
    [Google Scholar]
  7. Siurala M., Isokoscki M., Sipponen P. Gastritis.. In Demling L. ed Klinische gastroenterologie. vol I: Stuttgart, Thieme; 1984321–337
    [Google Scholar]
  8. Perez-Perez G I., Dworkin B M., Chodos J E., Blaser M J. Campylobacter pylori antibodies in humans. Ann Int Med 1988; 109:11–17
    [Google Scholar]
  9. Kaldor J., Tee W., Mc Carthy P., Watson J., Dwyer B. Immune response to Campylobacter pyloridis in patients with peptic ulceration. Lancet 1985; 1:921
    [Google Scholar]
  10. Rathbone B J., Wyatt J L., Worsley B W. et al. Systemic and local immune responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia. Gut 1986; 27:642–647
    [Google Scholar]
  11. Jones D M., Eldridge J., Fox A J., Sethi P., Whorwell P J. Antibody to the gastric campylobacter-like organism (“Campylobacter pyloridis”)—clinical correlations and distribution in the normal population. J Med Microbiol 1986; 22:57–62
    [Google Scholar]
  12. Newell D G., Johnston B J., Ali M H., Reed P J. An enzyme-linked immunosorbent assay for the serodiagnosis of Campylobacter pylori- associated gastritis. Scand J Gastroenterol 1988; 23:Suppl 14253–57
    [Google Scholar]
  13. Booth L., Holdstock G., Mc Bride H. et al. Clinical importance of Campylobacter pyloridis and associated serum IgG and IgA antibody responses in patients undergoing upper gastrointestinal endoscopy. J Clin Pathol 1986; 39:215–219
    [Google Scholar]
  14. Loffeld R J L F., Stobberingh E., van Spreeuwel J P., Arends J W. Diagnostic value of an immunoassay to detect anti-Campylobacter pylori antibodies in non-ulcer dyspepsia. Lancet 1989; 1:1182–1185
    [Google Scholar]
  15. Berkowicz J., Lee A. Person-to-person transmission of Campylobacter pylori. Lancet 1987; 2:680–681
    [Google Scholar]
  16. Wyatt J L., Rathbone B J., Heatley R V. Local immune response to gastric Campylobacter in non-ulcer dyspepsia. J Clin Pathol 1986; 39:863–870
    [Google Scholar]
  17. Herbrink P., van den Munckhof H A M., Bumkens M., Lindeman J., van Dijk W C. Human serum antibody response in Campylobacter jejuni enteritis as measured with enzyme-linked immunosorbent assay. Eur J Clin Microbiol Infect Dis 1988; 7:388–393
    [Google Scholar]
  18. von Wulffen H., Grote H J., Gatermann S., Loning T., Berger B., Buhl C. Immunoblot analysis of immune response to Campylobacter pylori and its clinical associations. J Clin Pathol 1988; 41:653–659
    [Google Scholar]
  19. Jones D M., Lessells A M., Eldridge J. Campylobacter-like organisms on the gastric mucosa: culture, histological, and serological studies. J Clin Pathol 1984; 37:1002–1006
    [Google Scholar]
  20. Dwyer B., Sun N X., Kaldor J. et al. Antibody response to Campylobacter pylori in an ethnic group lacking peptic ulceration. Scand J Infect Dis 1988; 20:63–68
    [Google Scholar]
  21. Rauws E A J., Langenberg W., Houthoff H J., Zanen H C., Tytgat G N J. Campylobacter pyloridis-associated chronic active antral gastritis: a prospective study of its prevalence and the effects of antibacterial and antinuclear treatment. Gastroenterology 1988; 94:3340
    [Google Scholar]
  22. Vaira D., Holton J., Cairns S R. et al. Antibody titres to Campylobacter pylori after treatment for gastritis. Br Med J 1988; 297:397
    [Google Scholar]
  23. Talley N J., McNeil D., Hayden A., Colreavy C., Piper D W. Prognosis of chronic unexplained dyspepsia: a prospective study of potential predictor variables in patients with endoscopically diagnosed non-ulcer dyspepsia. Gastroenterology 1987; 92:1060–1066
    [Google Scholar]
  24. Loffeld R J L F., Potters H V P J., Arends J W., Stobberingh E., Flendrig J A., van Spreeuwel J P. Campylobacter associated gastritis in patients with non-ulcer dyspepsia. J Clin Pathol 1988; 41:85–88
    [Google Scholar]
  25. Marshall B J., McGechie D B., Francis G J., Utley P J. Pyloric Campylobacter serology. Lancet 1984; 2:281
    [Google Scholar]
  26. Graham D Y., Klein P D., Opekun A R. et al. Epidemiology of Campylobacter pyloridis infection. Gastroenterology 1987; 92:1411
    [Google Scholar]
  27. Eldridge J., Jones D M. Longitudinal study of the incidence of antibody to Campylobacter pylori in schoolchildren. In Megrand F., Lamouliatte H. eds Gastroduodenal pathology and Campylobacter pylori. Proceedings of the 1st Meeting of the European Campylobacter pylori study group. Amsterdam: Excerpta Medica; 1989357–369
    [Google Scholar]
  28. Siurala M., Varis K V. Gastritis. In Sircus W., Smith A N. eds Scientific foundation of gastroenterology. London: Williams Heinemann; 1980357–369
    [Google Scholar]
  29. Joffe S N., Rao S S. Symptoms of gastritis. Scand J Gastroenterol 1982; 17 Suppl 79:62–65
    [Google Scholar]
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