1887

Abstract

The bactericidal activity of compound DR-3355, an optically active isomer of ofloxacin, was measured against and , in nutrient broth and in phosphate-buffered saline. DR-3355 was found to be approximately twice as active as ofloxacin in terms of the concentration at which maximum bacterial kill was achieved. Hence it appears that DR-3355 is twice as active as ofloxacin not only in terms of its ability to inhibit bacterial multiplication but also in its ability to kill bacteria. DR-3355 was found to be active against non-dividing bacteria and did not require either active RNA or protein biosynthesis in order to kill bacteria.

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/content/journal/jmm/10.1099/00222615-30-3-227
1989-11-01
2020-01-18
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-30-3-227
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