Radiometric selective inhibition tests were developed and evaluated for the rapid differentiation of spp. Both a -nitrobenzoic acid (PNB) test and a commercially-prepared -nitro-α-acetylamino-β-hydroxypropiophenone (NAP) test successfully differentiated and from ‘atypical’ mycobacteria or mycobacteria other than tubercle bacilli (MOTT). Thiophene-2-carboxylic acid hydrazide (TCH) readily distinguished human strains from , irrespective of resistance to isoniazid. Both PNB and TCH tests were utilised in a routine radiometric susceptibility testing scheme over a period of 1 year in which 110 isolates of , 10 of and one isolate of BCG were correctly differentiated from 10 isolates of MOTT. The rapidity, sensitivity and specificity of these radiometric tests can play a useful role in mycobacterial identification.


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