1887

Abstract

Summary

Five strains of mice (C3H, CBA, BALB/c, TO and ICR) were inoculated intra-vaginally with in an attempt to produce an animal model of gonorrhoea. Of a total of 68 mice inoculated, only three (4.4%) were culture-positive after 3 days. Histological examination of both the genital mucosa of inoculated animals, and the mucosa of genital tract organ cultures inoculated failed to show any evidence of gonococcal adherence or colonisation. Mice of these strains, therefore, appear resistant to gonococcal infection of the genital tract.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-30-1-33
1989-09-01
2022-07-01
Loading full text...

Full text loading...

/deliver/fulltext/jmm/30/1/medmicro-30-1-33.html?itemId=/content/journal/jmm/10.1099/00222615-30-1-33&mimeType=html&fmt=ahah

References

  1. Baker D. A., Plotkin S. A. 1978; Enhancement of vaginal infection in mice by herpes simplex virus type II with progesterone. Proceedings of the Society for Experimental Biology and Medicine 158:131–134
    [Google Scholar]
  2. Braude A. L., Corbeil L. B., Levine S., Ito J., McCutchan J. A. 1978; Possible influences of cyclic menstrual changes on resistance to the gonococcus. In Brooks G. F. (eds) Immunobiology of Neisseria gonorrhoeae American Society for Microbiology; Washington DC: pp 307–313
    [Google Scholar]
  3. Chandler F. W., Kraus S. J. 1976; Animal model of human disease: Experimental gonorrhea in the chimpanzee. American Journal of Pathology 82:437–440
    [Google Scholar]
  4. DiGiacomo R. F., Gale J. L., Holmes K. K., Buchanan T. M. 1977; Genital inoculation of male baboons with Neisseria gonorrhoeae. Infection and Immunity 15:670–671
    [Google Scholar]
  5. Furr P. M., Taylor-Robinson D. 1984; Enhancement of experimental Mycoplasma pulmonis infection of the mouse genital tract by progesterone treatment. Journal of Hygiene 92:139–144
    [Google Scholar]
  6. Gale J. L., DiGiacomo R. F., Kiviat M. D., Wang S.-P., Bowie W. R. 1977; Experimental nonhuman primate urethral infection with Chlamydia trachomatis and Ureaplasma (Tmycoplasma). In Hobson D., Holmes K. K. (eds) Nongonococcal urethritis and related infections American Society for Microbiology; Washington DC: pp 205–213
    [Google Scholar]
  7. Johnson A. P., Clark J. B., Osborn M. F., Taylor-Robinson D. 1980; A comparison of the association of Neisseria gonorrhoeae with human and guinea-pig genital mucosa maintained in organ culture. British Journal of Experimental Pathology 61:521–527
    [Google Scholar]
  8. Johnson A. P., Taylor-Robinson D., McGee Z. A. 1977a; Species specificity of attachment and damage to oviduct mucosa by Neisseria gonorrhoeae. Infection and Immunity 18:833–839
    [Google Scholar]
  9. Johnson A. P., Taylor-Robinson D., Slavin G. 1977b; Pneumonia in mice produced by Neisseria gonorrhoeae. British Journal of Venereal Diseases 53:26–30
    [Google Scholar]
  10. Kellogg D. S., Peacock W. L., Deacon W. E., Brown L., Pirkle C. I. 1963; Neisseria gonorrhoeae. I. Virulence genetically linked to clonal variation. Journal of Bacteriology 85:1274–1279
    [Google Scholar]
  11. Kita E., Matsuura H., Kashiba S. 1981; A mouse model for the study of gonococcal genital infection. Journal of Infectious Diseases 143:67–70
    [Google Scholar]
  12. Sowter C., McGee Z. A. 1976; Evaluation of a new technique for the demonstration of gonococci and other micro-organisms in host cells. Journal of Clinical Pathology 29:433–437
    [Google Scholar]
  13. Taylor-Robinson D., Johnson A. P., McGee Z. A. 1975; Use of organ cultures and small laboratory animals for the study of gonococcal infections. In Danielsson D. (eds) Genital infections and their complications Almqvist and Wiksell; Stockholm: pp 243–252
    [Google Scholar]
  14. Taylor-Robinson D., Whytock S., Green C. J., Carney F. E. 1974; Effect of Neisseria gonorrhoeae on human and rabbit oviducts. British Journal of Venereal Diseases 50:279–288
    [Google Scholar]
  15. Tebbutt G. M., Veale D. R., Penn C. W., Smith H. 1977; The behaviour of Neisseria gonorrhoeae on guinea-pig mucosae in vitro and in vivo. FEMS Microbiology Letters 2:39–41
    [Google Scholar]
  16. Tuffrey M., Taylor-Robinson D. 1981; Progesterone as a key factor in the development of a mouse model for genital-tract infection with Chlamydia trachomatis. FEMS Microbiology Letters 12:111–115
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-30-1-33
Loading
/content/journal/jmm/10.1099/00222615-30-1-33
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error