1887

Abstract

SUMMARY

A case of staphylococcal empyema is presented in which resolution was slow in spite of apparently adequate therapy with cloxacillin. A relapse occurred when the drug was stopped after 2 wk because of the appearance of a rash. On two occasions while the patient was being treated with cloxacillin, large numbers of colonies of the bacterial form of appeared on plates of L-form medium but not on control plates without osmotic stabilisers. Relapse was associated with the re-emergence of staphylococci that could be isolated on conventional media, and a similar reversion of L-colonies made from the patient’s organism could be demonstrated on prolonged incubation. The infection was finally eradicated by erythromycin, novobiocin and drainage. It is suggested that cultures on L-form medium should be set up in any severe staphylococcal infection that fails to respond to chemotherapy and drainage, and that combined therapy with methicillin and an antibiotic that does not act on the cell wall should be considered.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-3-4-669
1970-11-01
2021-10-27
Loading full text...

Full text loading...

/deliver/fulltext/jmm/3/4/medmicro-3-4-669.html?itemId=/content/journal/jmm/10.1099/00222615-3-4-669&mimeType=html&fmt=ahah

References

  1. Barber Mary. 1962 In Resistance of bacteria to the penicillins. Ciba Fdn Study Grp no. 13, p 91
    [Google Scholar]
  2. Brier G., Ellis L., Godzeski G. W. 1963 In Antimicrobial agents and chemotherapy, 1962 ed. by Sylvester J. C. Ann Arbor: p 854
    [Google Scholar]
  3. Charache Patricia. 1968 In Microbial protoplasts, spheroplasts, and L-forms ed. by Guze L. B. Baltimore: p 484
    [Google Scholar]
  4. Elek S. D., Hilson G. R. F. 1954 J. Clin. Path 7:37
    [Google Scholar]
  5. Feingold D. S. 1969 New Engl. J. Med 281:1159
    [Google Scholar]
  6. Gooder H. 1968 In Microbial protoplasts, spheroplasts, and L-forms ed. by Guze L. B. Baltimore: p 46
    [Google Scholar]
  7. Gutman Laura T., Schaller Jane, Wedgwood R. J. 1967 Lancet 1:464
    [Google Scholar]
  8. Gutman Laura T., Turck M., Peters-dorf R. G., Wedgwood R. J. 1965 J. Clin. Invest 44:1945
    [Google Scholar]
  9. Guze L. B., Kalmanson G. M. 1964 Science, N,. Y 143:1340
    [Google Scholar]
  10. Jensen K., Lassen H. C. A. 1969 Q. J. Med 38:91
    [Google Scholar]
  11. Kagan B. M. 1968 In Microbial protoplasts, spheroplasts, and L-forms ed. by Guze L. B. Baltimore: p 372
    [Google Scholar]
  12. Kagan B. M., Molander C. W., Zolla Susan, Heimlich E. M., Weinberger H. J., Busser R., Liepnieks S. 1964 In Antimicrobial agents and chemotherapy, 1963 ed. by Sylvester J. C. Ann Arbor: p 517
    [Google Scholar]
  13. Mortimer E. 1968 In Microbial protoplasts, spheroplasts, and L-forms ed. by Guze L. B. Baltimore: p 345
    [Google Scholar]
  14. Neu H. C., Goldreyer B. 1968 Amer. J. Med 45:784
    [Google Scholar]
  15. Newsom S. W. B. 1967 Br. Med. J 3:678
    [Google Scholar]
  16. Perret C. J. 1954 Nature, Lond 174:1012
    [Google Scholar]
  17. Williams R. E. 1963 J. Gen. Microbiol 33:325
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-3-4-669
Loading
/content/journal/jmm/10.1099/00222615-3-4-669
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error