Enhancement Of The Potency Of Typhoid Vaccines With Calcium Alginate

The potency of typhoid vaccine for mice could be increased 50-fold by incorporation in alginate. This adjuvance was evident only after intraperitoneal inoculation. It waned rapidly and had virtually ceased 26 days after vaccination.

Similarly, alginate increased the resistance to typhoid challenge of mice given a heterologous antigen, pertussis vaccine, provided this was injected intraperitoneally.

Alginate alone, when injected intraperitoneally, but not when injected subcutaneously, increased the resistance of mice to typhoid challenge.

It was concluded that the adjuvance of typhoid vaccine by alginate resulted from stimulation of antibacterial mechanisms in the peritoneal cavity and was independent of any specific immune mechanism.