The minimum inhibitory concentrations of trimethoprim and sulphamethoxazole were determined for 209 strains of isolated mainly in the Greater London area. All strains were sensitive to trimethoprim at a concentration of 0.32 µg per ml, but 74 per cent. of strains were resistant to sulphamethoxazole at a concentration of 100 µg per ml.

Potentiation of trimethoprim by sulphamethoxazole was demonstrated in the case of sulphonamide-sensitive strains but there was little or no potentiation in the case of sulphonamide-resistant strains.

The possible value of the combination of trimethoprim and sulphamethoxazole in the treatment of Sonne dysentery is discussed briefly.


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  1. Abbott J. D., Graham J. M. 1961 Mon. Bull. Minist. Hlth 20:51
    [Google Scholar]
  2. Abbott J. D., Shannon R. 1958 J. Clin. Path 11:71
    [Google Scholar]
  3. Bushby S. R. M. 1969 Postgrad. Med. J 45: Suppl., p 10
    [Google Scholar]
  4. Darrell J. H., Garrod L. P., Waterworth Pamela M. 1968 J. Clin. Path 21:202
    [Google Scholar]
  5. Davies Joan R., Farrant W. N., Tomlinson A. J. H. 1968 J. Hyg., Camb 66:479
    [Google Scholar]
  6. Farrant W. N., Tomlinson A. J. H. 1966 Ibid 64:287
    [Google Scholar]
  7. Scrimgeour G. 1966 Mon. Bull. Minist. Hlth 25:278
    [Google Scholar]

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