1887

Abstract

SUMMARY

The minimum inhibitory concentrations of trimethoprim and sulphamethoxazole were determined for 209 strains of isolated mainly in the Greater London area. All strains were sensitive to trimethoprim at a concentration of 0.32 µg per ml, but 74 per cent. of strains were resistant to sulphamethoxazole at a concentration of 100 µg per ml.

Potentiation of trimethoprim by sulphamethoxazole was demonstrated in the case of sulphonamide-sensitive strains but there was little or no potentiation in the case of sulphonamide-resistant strains.

The possible value of the combination of trimethoprim and sulphamethoxazole in the treatment of Sonne dysentery is discussed briefly.

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/content/journal/jmm/10.1099/00222615-3-3-554
1970-08-01
2021-10-27
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