%0 Journal Article %A Torres Pereira, A. %A Goldberg, Stanislawa S. %T Virulence Of Staphylococcus Aureus Tested By Intracerebral Inoculation Into Mice %D 1970 %J Journal of Medical Microbiology, %V 3 %N 3 %P 547-550 %@ 1473-5644 %R https://doi.org/10.1099/00222615-3-3-547 %I Microbiology Society, %X SUMMARY When tested by intracerebral injection in mice, a strain of Staphylococcus aureus containing antigen 17 was found to be much more virulent than a variant that lost this antigen and contained antigen 1 in its place. Since 85.7 per cent. of the mice challenged died between 7 1 2 and 11 1 2 hr after inoculation it is suggested that a toxin was the cause of death. A standardised test by intracerebral inoculation is considered to be a useful test of virulence in mice. Out of 100 recently isolated coagulase-positive strains assessed by this method, only 18 were considered to be avirulent. The degree of virulence was correlated with the clinical source of the strains. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-3-3-547