Cephalexin, cephaloridine and 7-(thienyl-2'-acetamido)-3-methylceph-3-em-4-carboxylic acid (TMC) were injected directly into the alimentary tract of rats and their subsequent fate was studied. The three antibiotics showed respectively good, poor and intermediate degrees of absorption from the alimentary tract. These differences are attributable to the rate at which each antibiotic is absorbed from the small intestine and not to the amount of degradation that occurs in the gut.

Cephalexin is much more rapidly absorbed from the small intestine than are cephaloridine and TMC. Cephalosporins that are not absorbed in the small intestine pass down the alimentary tract and are destroyed when they reach the caecum, from which there is little absorption.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error