The sequential changes occurring during bacillary division of in infected foot-pads of mice and human skin and nerves were studied with the electron microscope and found to be as follows: (1) a slight concavity develops in the plasma membrane, (2) two new electron-dense cell-wall layers are found between the concavity and the original cell wall, and an electrontransparent cell-wall layer appears between them, and gradually separates them, and (3) the annular ingrowth of the plasma membrane and cell wall proceeds until division is complete. There is no essential difference between the behaviour of and that of other mycobacteria, nor between the behaviour in bacteria obtained from human biopsy specimens and bacteria from infected mice. Although multiplies slowly the actual process of cell division may be relatively rapid.


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