1887

Abstract

SUMMARY

The isoquinoline drugs UK2054 and UK2371 were tested for activity against rhino-viruses. UK2054, but not UK2371, decreased the yield of rhinovirus types 2, 4, 9 and 43 from HeLa cells maintained in medium containing the drug. This activity was not demonstrable in a semi-continuous line of human embryo lung fibroblasts, HEL-218. In a double-blind, placebo-controlled trial, human volunteers were experimentally infected with rhinovirus type 9 and given prophylactic and therapeutic UK2054 by mouth. No significant antiviral activity was found in this trial.

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1970-05-01
2021-10-26
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References

  1. Beare A. S., Bynoe M. L., Tyrrell D. A. J. 1968 Lancet 1:843
    [Google Scholar]
  2. Brammer K. W., McDonald C. R., Tute M. S. 1968 Nature, Lond 219:515
    [Google Scholar]
  3. Larin N. M., Beare A. S., Copping M. P., McDonald C. R., McDougall J. K., Roberts B., Smith J. B. 1968 In Antimicrobial agents and chemotherapy, 1967 ed. by FIobby Gladys L. Ann Arbor: p 646
    [Google Scholar]
  4. Reed Sylvia E., Beare A. S., Bynoe M. L., Tyrrell D. A. J. 1969 Ann. N,. Y. Acad. Sci in press
    [Google Scholar]
  5. Stott E. J., Tyrrell D. A. J. 1968 Arch. ges. Virusforsch 23:236
    [Google Scholar]
  6. Tyrrell D. A. J. 1963 Amer. Rev. Resp. Dis 88:128
    [Google Scholar]
  7. Meenan P. N., Hillary I. 1969a Lancet 2:614
    [Google Scholar]
  8. Meenan P. N., Hillary I. 1969b Ibid 2:641
    [Google Scholar]
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