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The isoquinoline drugs UK2054 and UK2371 were tested for activity against rhino-viruses. UK2054, but not UK2371, decreased the yield of rhinovirus types 2, 4, 9 and 43 from HeLa cells maintained in medium containing the drug. This activity was not demonstrable in a semi-continuous line of human embryo lung fibroblasts, HEL-218. In a double-blind, placebo-controlled trial, human volunteers were experimentally infected with rhinovirus type 9 and given prophylactic and therapeutic UK2054 by mouth. No significant antiviral activity was found in this trial.
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