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Volume 3, Issue 1

Enhancement Of Intracerebral Infection Of Mice With Free

Abstract

SUMMARY

Intracerebral infection of mice with low-virulence strains of was greatly enhanced by the prior administration of cortisone acetate subcutaneously or of vitamin-A alcohol or streptolysin O intracerebrally.

The infections did not appear to stimulate the release of lysosomal enzymes in the brain.

When normal mice were X-irradiated to the head, with the body shielded, subsequent intracerebral infection with low-virulence strains was very much enhanced. Irradiation of the head alone did not affect the survival of actively immunised mice after the intracerebral injection of either high-virulence or low-virulence strains, but irradiation of the body, with the head shielded, significantly reduced the number of survivors after infection with a high-virulence strain.

It appears that a cerebral glial response controls intracerebral infections with low-virulence strains in normal mice, but that circulating leucocytes play a major role in controlling infections with high-virulence strains in immunised mice.

  • Received:
  • Accepted:
  • Revised:
  • Published Online:
© J. Med. Microbiol. 1970
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1970-02-01
2024-04-25
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References

  1. Abblson D., Baron D. N., ToakLey J. G. 1955 J. Endocr 12:87
     [Google Scholar]
  2. Adams G. J. J. 1968 Ph.D. Thesis, Univ London:
  3. Adams G. J. 1970 J.Med. Microbiol 3:1
     [Google Scholar]
  4. Baron D. N., Abelson D. 1954 Nature, Lond 173:174
     [Google Scholar]
  5. Becker N. H., Goldfischer S., Shin W. Y., Novikoff A. B. 1960 J. Biophys. Biuchem. Cytol 8:649
     [Google Scholar]
  6. Becker N. H., Sutton C. H. 1963 Amer. J. Path 43:1017
     [Google Scholar]
  7. Berenbaum M. C., Ungar J., Stevens W. K. 1960 J. Gen. Microbiol 22:313
     [Google Scholar]
  8. Christy N. P., Fishman R. A. 1961 J. Clin. Invest 40:1997
     [Google Scholar]
  9. Clements C. D. 1958 J. Comp. Neurol 109:123
     [Google Scholar]
  10. Dacie J. V., Lewis S. M. 1963; Practical haematology. 3rd ed London p 51
     [Google Scholar]
  11. Fell Honor B. 1962 J. Embryol. Exp. Morph 10:389
     [Google Scholar]
  12. Field E. J. 1957 J. Neuropath. Exp. Neurol 16:48
     [Google Scholar]
  13. Foley J. M., Chambers R. A., Adams R. D. 1953 Ibid 12:101
     [Google Scholar]
  14. Hirsch J. G., Bernheimer A. W., Weissman G. 1963 J. Exp. Med 118:223
     [Google Scholar]
  15. Holt L. B., Spasojevic Vera Dolby Jean M., Standfast A. F. B. 1961 J. Hyg., Camb 59:373
     [Google Scholar]
  16. Hopewell J. W., Adams G. J. 1970 Expl Neurol 26, January
    [Google Scholar]
  17. Hopewell J. W., Wright E. A. 1967 Nature, Lond 215:1405
     [Google Scholar]
  18. Hunter G. D., Millson G. C. 1966 J. Neurochem 13:375
     [Google Scholar]
  19. Iida T., Kunitani A., Komase Y., Yamamoto A. 1963 Jap. J. Exp. Med 33:283
     [Google Scholar]
  20. Iida T., Kusano N., Yamamoto A., Konoso M. 1966 J. Path. Bact 92:359
     [Google Scholar]
  21. Iida T., Kusano N., Yamamoto A., Shiga H. 1962 Jap. J. Exp. Med 32:471
     [Google Scholar]
  22. Langman J., Welch G. W. 1966 J. Comp. Neurol 128:1
     [Google Scholar]
  23. Langman J., Welch G. W. 1967 Ibid 131:15
     [Google Scholar]
  24. Millson G. C. 1965 J. Neurochem 12:461
     [Google Scholar]
  25. Naidoo D., Pratt O. E. 1951 J. Neurol. Neurosurg. Psychiat 14:287
     [Google Scholar]
  26. Sutton C. H. 1965 Bull. N. Y. Acad. Med 41:326
     [Google Scholar]
  27. Weissman G. 1964 Blood 24:594
     [Google Scholar]
  28. Weissman G., Keiser H., Bern HEIMER A. W. 1963 J. Exp. Med 118:205
     [Google Scholar]
  29. Weissman G., Thomas L. 1962 Ibid 116:433
     [Google Scholar]
  30. Weissman G., Thomas L. 1963 J. Clin. Invest 42:661
     [Google Scholar]
  31. Wolf A., Kabat E. A., Newman W. 1943 Amer. J. Path 19:423
     [Google Scholar]
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Enhancement Of Intracerebral Infection Of Mice With Bordetella Pertussis
J. Med. Microbiol. 3, 15 (1970); https://doi.org/10.1099/00222615-3-1-15
/content/journal/jmm/10.1099/00222615-3-1-15
/content/journal/jmm/10.1099/00222615-3-1-15
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