1887

Abstract

SUMMARY

A coagulase-positive strain of grown (strain O) was passaged in rabbits to increase virulence. The passaged organisms grown (strain P) were used to infect rabbits from which organisms grown (strain V) were isolated.

By LD50 measurement in rabbits, strain V was 25 times more virulent than strain P and 6000 times more virulent than strain O. On incubation in rabbit serum, strain V multiplied whilst strains P and O decreased in viable number (strain O the more rapidly) during the first 3 hr, recovering subsequently. In lysates of polymorphonuclear leucocytes, strain V multiplied or was slightly reduced in number; strains P and O decreased in number (strain O the more rapidly).

The findings suggest that resistance to serum and polymorph bactericidins is an important attribute of the virulence of staphylococci and that the substances responsible are qualitatively different or quantitatively increased on growth

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-3-1-147
1970-02-01
2024-05-23
Loading full text...

Full text loading...

/deliver/fulltext/jmm/3/1/medmicro-3-1-147.html?itemId=/content/journal/jmm/10.1099/00222615-3-1-147&mimeType=html&fmt=ahah

References

  1. Adlam C., Pearce J. H., Smith H. 1968 Nature, Lond 219:641
    [Google Scholar]
  2. Alexander J. W., Good R. A. 1968 J. Lab. Clin. Med 71:971
    [Google Scholar]
  3. Beining P. R., Kennedy E. R. 1963 J. Bact 85:732
    [Google Scholar]
  4. Cohn Z. A., Morse S. I. 1959 J. Exp. Med 110:419
    [Google Scholar]
  5. Cowan S. T., Steel K. J. 1965; Manual for the identification of medical. bacteria Cambridge:
    [Google Scholar]
  6. Cybulska Janina, Jeljaszewicz J. 1966 J. Bact 91:953
    [Google Scholar]
  7. Ekstedt R. D. 1956 Ibid 72:157
    [Google Scholar]
  8. Ekstedt R. D. 1965 Ann. N. Y. Acad. Sci 128:301
    [Google Scholar]
  9. Fisher S. 1963 J. Infect. Dis 113:213
    [Google Scholar]
  10. Fisher S. 1965 Ibid 115:285
    [Google Scholar]
  11. Gellenbeck S. Mercy. 1962 J. Bact 83:450
    [Google Scholar]
  12. Gladstone G. P., Glencross E. J. G. 1960 Br. J. Exp. Path 41:313
    [Google Scholar]
  13. Hektoen L. 1906 J. Amer. Med. Assoc 46:1407
    [Google Scholar]
  14. Hill M. J. 1968 J. Med. Microbiol 1:33
    [Google Scholar]
  15. Hirsch J.G. 1960 J. Exp. Med 112:15
    [Google Scholar]
  16. Kourilsky R., Mercier P. 1941a C. r. Séanc. Soc. Biol 135:803
    [Google Scholar]
  17. Kourilsky R., Mercier P. 1941b Ibid 135:1267
    [Google Scholar]
  18. Kourilsky R., Mercier P. 1941c Ibid 135:1424
    [Google Scholar]
  19. Litchfield J. T., Wilcoxon F. 1949 J. Pharmac. Exp. Ther 96:99
    [Google Scholar]
  20. Meynell G. G. 1961 Symp. Soc. Gen. Microbiol 11:174
    [Google Scholar]
  21. Miles A. A., Miles Ellen M., Burke J. 1957 Br. J. Exp. Path 38:79
    [Google Scholar]
  22. Morse S. I. 1965 In Bacterial and mycotic infections of man 4th ed., edited by Dubos R. J., Hirsch J. G. London: p 412
    [Google Scholar]
  23. Myrvik Q. N. 1956 Ann. N. Y. Acad. Sci 66:391
    [Google Scholar]
  24. Rogers D. E., Melly Marion A. 1965 Ibid 128:274
    [Google Scholar]
  25. Simon H. J. 1965 Ibid 128:351
    [Google Scholar]
  26. Skarnes R. C., Watson D. W. 1957 Bact. Rev 21:273
    [Google Scholar]
  27. Smith H. 1964 Symp. Soc. Gen. Microbiol 14:1
    [Google Scholar]
  28. Taubler J. H., Kapral F. A. 1966 J. Infect. Dis 116:277
    [Google Scholar]
  29. Toshkov A., Droumchev I., Abrashev I. 1966 Izv. Microbiol. Inst. Bulg. Akad. Nauk 18203 (abstracted in Chem. Abstr. 1967, 67, 2821, abstr. no. 30009)
    [Google Scholar]
  30. Van de Velde H. 1894 Cellule 10:401
    [Google Scholar]
  31. Worms R. 1966 Postepy Mikrobioi 5:473
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-3-1-147
Loading
/content/journal/jmm/10.1099/00222615-3-1-147
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error