The effect of sub-inhibitory concentrations of 16 antibacterials on the bactericidal activity of the 4-quinolones nalidixic acid, ciprofloxacin and ofloxacin against Escherichia coli KL16 in nutrient broth was investigated. Sub-inhibitory concentrations of rifampicin, clindamycin, chloramphenicol, erythromycin or tetracycline antagonised the bactericidal activity of the 4-quinolones. Conversely, all seven aminoglycosides tested enhanced the bactericidal activity of the 4-quinolones whereas the cell wall antagonists, azlocillin, mezlocillin, ceftazidime and vancomycin had no effect on the bactericidal activity of the 4-quinolones.
AmyesS. G. B.1982; Bactericidal activity of trimethoprim alone and in combination with sulfamethoxazole in susceptible and resistant Escherichia coli K12. Antimicrobial Agents and Chemotherapy 21:288–293
BustamenteC. I.,
DrusanoG. L.,
WhartonR. C.,
WadeJ. C.1987; Synergism of the combinations of imipenem plus ciprofloxacin and imipenem plus amikacin against Pseudomonas aeruginosa and other bacterial pathogens. Antimicrobial Agents and Chemotherapy 31:632–634
ChalkleyL. J.,
KoornhofH. J.1985; Antimicrobial activity of ciprofloxacin against Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus determined by the killing curve method: antibiotic comparisons and synergistic interactions. Antimicrobial Agents and Chemotherapy 28:331–342
DaviesG. S. R.,
CohenJ.1985; In vitro study of the activity of ciprofloxacin alone and in combination against strains of Pseudomonas aeruginosa with multiple antibiotic resistance. Journal of Antimicrobial Chemotherapy 16:713–717
DavisB. D.,
ChenL.,
TaiP. C.1986; Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides. Proceedings of the National Academy of Sciences of the USA 83:6164–6168
DietzW. H.,
CookT. M.,
GossW. A.1966; Mechanism of action of nalidixic acid on Escherichia coli. III. Conditions required for lethality. Journal of Bacteriology 91:768–773
GiamarellouH.,
PetrikkosG.1987; Ciprofloxacin interaction with imipenem and amikacin against multiresistant Pseudomonas aeruginosa. Antimicrobial Agents and Chemotherapy 31:959–961
LewinC. S.1987; Interactions of 4-quinolone antibacterials and antibiotics with gram negative and positive bacteria. Ph. D. thesis University of London;
MatsunagaK.,
YamakiH.,
NishimuroT.,
TanakaN.1986; Inhibition of DNA replication initiation by aminoglycoside antibiotics. Antimicrobial Agents and Chemotherapy 30:468–474
NeuH. C.,
LabthavikulP.1982; In vitro activity of norfloxacin, a quinolone-carboxylic acid, compared with that of Ã-lactams, aminoglycosides and trimethoprim. Antimicrobial Agents and Chemotherapy 22:23–27
SmithG. M.,
LeylandM. J.,
FarrellI. D.,
GeddesA. M.1988; A clinical microbiological and pharmacokinetic study of ciprofloxacin plus vancomycin as initial therapy of febrile episodes in neutropenic patients. Journal of Antimicrobial Chemotherapy 21:647–655
SmithS. M.,
EngR. H. K.,
BermanE.1986; The effect of ciprofloxacin on methicillin-resistant Staphylococcus aureus. Journal of Antimicrobial Chemotherapy 17:287–295
TaiP. C.,
DavisB. D.1985; The actions of antibiotics on the ribosome. In
GreenwoodD.,
O’GradyF.
(eds) The scientific basis of antimicrobial chemotherapy Cambridge University Press; Cambridge: pp 45–69
TanakaN.1982; Mechanism of action of the aminoglycoside antibiotics. In
UmezawaH.,
HooperI. R.
(eds) Aminoglycoside antibiotics; Handbook of experimental pharmacology vol 62 Springer-Verlag, Berlin, Heidelberg; New York: pp 221–226
TanakaN.,
MatsunagaK.,
YamakiH.,
NishimuraT. K.1984; Inhibition of initiation of DNA synthesis by aminoglycoside antibiotics. Biochemical and Biophysical Research Communications 122:460–465
Van der AuweraP.1985; Interaction of gentamicin, dibekacin, netilmicin and amikacin with various penicillins, cephalosporins, minocycline and new fluoro-quinolones against Enterobacteriaceae and Pseudomonas aeruginosa. Journal of Antimicrobial Chemotherapy 16:581–587
WolfsonJ. S.,
HooperD. C.1985; The fluoroquinolones: Structures, mechanisms of action and resistance and spectra of activity in vitro. Antimicrobial Agents and Chemotherapy 28:581–586