1887

Abstract

Summary

Endocarditis is a rather frequent complication of Q fever caused by We examined the ability of phase I (virulent) or phase II (avirulent) to coagulate blood in the presence of human blood mononuclear cells After incubation for 4 h, virulent phase I was an effective stimulant for mononuclear cells. Since this interaction is a potent trigger of blood coagulation through the extrinsic pathway, it could be responsible for the local deposition of fibrin on the surface of infected valves and the development of large vegetations in cases of endocarditis complicating Q fever.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-29-1-9
1989-05-01
2022-05-20
Loading full text...

Full text loading...

/deliver/fulltext/jmm/29/1/medmicro-29-1-9.html?itemId=/content/journal/jmm/10.1099/00222615-29-1-9&mimeType=html&fmt=ahah

References

  1. Baca O. G., Paretsky D. 1983; Q fever and Coxiella burnetii: a model for host-parasite interactions. Microbiological Reviews 47:127–149
    [Google Scholar]
  2. Biggs R. 1972; Human blood coagulation, hemostasis and thrombosis. Blackwell scientific Publications; Oxford: p 288
    [Google Scholar]
  3. Boyüm A. 1968; Isolation of leucocytes from human blood. A two-phase system for removal of red cells with methylcellulose as erythrocyte-aggregating agent. Scandinavian Journal of Clinical and Laboratory Investigation 21: Suppl 979–29
    [Google Scholar]
  4. Burnet F. M., Freeman M. 1937; Experimental studies on the virus of‘Q’ fever. Medical Journal of Australia 2:299–305
    [Google Scholar]
  5. Constantinidis K., Jenkins J. P. R. 1979; Chronic Q fever endocarditis. Practical Medicine 222:533–536
    [Google Scholar]
  6. Derrick E. H. 1937; Q fever, a new fever entity: clinical features, diagnosis and laboratory investigations. Medical Journal of Australia 2:281–299
    [Google Scholar]
  7. Drake T. A., Rodgers G. M., Sande M. A. 1984; Tissue factor is a major stimulus for vegetation formation in enterococcal endocarditis in rabbits. Journal of Clinical Investigation 73:1750–1753
    [Google Scholar]
  8. Durack D. T. 1975; Experimental bacterial endocarditis. IV. Structure and evolution of very early lesions. Journal of Pathology 115:81–91
    [Google Scholar]
  9. Giroud P. 1976; Les lesions cardio-vasculaires des rickettsioses et des chlamydioses (Neorickettsioses). Angeiologie 28:175–182
    [Google Scholar]
  10. Goutner A., Beguin S., Josso F. 1975; Tissue factor activity of cultured human lymphocytes. Biomedicine 22:298–302
    [Google Scholar]
  11. Kazar J., Brezina R., Schramek S., Urvolgyi J., Pospisil V., Kovacova E. 1974; Virulence, antigenic properties and physico-chemical characteristics of Coxiella burnetii strains with different chick embryo yolk sac passage history. Acta Virologica 18:434–442
    [Google Scholar]
  12. Kazar J., Schramek S., Zajacova S. 1983; Induction of splenomegaly in mice by killed Coxiella burnetii cells. Acta Virologica 27:65–70
    [Google Scholar]
  13. Kimbrough R. C. 1979; Q fever endocarditis in the United States. Annals of Internal Medicine 91:400–402
    [Google Scholar]
  14. Kimbrough R. C., Ormsbee R. A., Peacock M. G. 1981; Q fever endocarditis: a three and one-half year follow-up. In Burgdorfer W., Anacker R. L. (eds) Rickettsiae and rickettsial diseases Academic Press, Inc; New York: p 125
    [Google Scholar]
  15. Lerner R. G., Goldstein R., Cummings G. 1971; Stimulation of human leukocyte thromboplastic activity by endotoxin. Proceedings of the Society for Experimental Biology and Medicine 138:145–148
    [Google Scholar]
  16. Li C. Y., Lam K. W., Yam L. T. 1973; Esterases in human leukocytes. Journal of Histochemistry and Cytochemistry 21:1–12
    [Google Scholar]
  17. Miragliotta G., Semeraro N., Marcuccio L., Fumarola D. 1982; Legionella pneumophila and related organisms induce the generation of procoagulant activity by peripheral mononuclear cells in vitro. Infection 10:215–218
    [Google Scholar]
  18. Miragliotta G., Fumarola D. 1983; In vitro effect of Leptospira icterohaemorrhagiae on human mononuclear leukocytes procoagulant activity: comparison of virulent with nonvirulent strain. Canadian Journal of Comparative Medicine 47:70–72
    [Google Scholar]
  19. Niemetz J., Fani K. 1971; Role of leukocytes in blood coagulation and the generalised Schwartzman reaction. Nature 232:247–248
    [Google Scholar]
  20. Osterud B., Bjørklid E. 1982; The production and availability of tissue thromboplastin in cellular populations of whole blood exposed to various concentrations of endotoxin. An assay for detection of endotoxin. Scandinavian Journal of Haematology 29:175–184
    [Google Scholar]
  21. Palmer S. R., Young S. E. J. 1982; Q fever endocarditis in England and Wales, 1975–1981. Lancet 2:1448–1449
    [Google Scholar]
  22. Raoult D., Piquet Ph., Gallais H., De Micco C., Drancourt M., Casanova P. 1986; Coxiella burnetii infection of a vascular prosthesis. New England Journal of Medicine 315:1358–1359
    [Google Scholar]
  23. Robson A. O., Shimmin C. D. G. L. 1959; Chronic Q fever. 1. Clinical aspects of a patient with endocarditis. British Medical Journal 2:980–983
    [Google Scholar]
  24. Rosman M. S., Lubbe W. F., Hayden M., Basson N., Uys C. J. 1977; Q fever endocarditis: a report of two cases. South African Medical Journal 53:296–300
    [Google Scholar]
  25. Thorig L., Thompson J., Eulderink F. 1977; Effect of warfarin on the induction and course of experimental Staphylococcus epidermidis endocarditis. Infection and Immunity 17:504–509
    [Google Scholar]
  26. Tobin M. J. 1982; Q fever endocarditis. American Journal of Medicine 72:396–400
    [Google Scholar]
  27. van Ginkel C. J. W., Thorig L., Thompson J., Oh J. I. H., van Aken W. G. 1979; Enhancement of generation of monocyte tissue thromboplastin by bacterial phagocytosis: possible pathway for fibrin formation on infected vegetations in bacterial endocarditis. Infection and Immunity 25:388–395
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-29-1-9
Loading
/content/journal/jmm/10.1099/00222615-29-1-9
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error