@article{mbs:/content/journal/jmm/10.1099/00222615-28-3-191, author = "Yamamoto, K. and Suzuki, K. and Suzuki, K. and Mizuno, S.", title = "Phagocytosis and ingestion of influenza virus by human polymorphonuclear leucocytes in vitro: Electronmicroscopy studies", journal= "Journal of Medical Microbiology", year = "1989", volume = "28", number = "3", pages = "191-198", doi = "https://doi.org/10.1099/00222615-28-3-191", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-28-3-191", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "SUMMARY Interaction of human polymorphonuclear leucocytes (PMNL) and influenza virus (IFV) was studied in vitro. At 0°C, the viral particles were bound extensively to the surface of the PMNL membrane with a ratio of about 1000 virus particles to a single PMNL. The binding was sensitive to neuraminidase, suggesting attachment through sialo-compound receptors. At 37°C, the virus particles disappeared rapidly from the cell surface, about half of them being eluted and the remainder being endocytosed into the cytoplasmic vesicles. Immuno-gold electronmicroscopy suggests that the virus particles are ingested into phagosomal vesicles and lysed.", }