1887

Abstract

Interaction of human polymorphonuclear leucocytes (PMNL) and influenza virus (IFV) was studied in . At 0°C, the viral particles were bound extensively to the surface of the PMNL membrane with a ratio of about 1000 virus particles to a single PMNL. The binding was sensitive to neuraminidase, suggesting attachment through sialo-compound receptors. At 37°C, the virus particles disappeared rapidly from the cell surface, about half of them being eluted and the remainder being endocytosed into the cytoplasmic vesicles. Immuno-gold electronmicroscopy suggests that the virus particles are ingested into phagosomal vesicles and lysed.

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/content/journal/jmm/10.1099/00222615-28-3-191
1989-03-01
2019-10-21
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-28-3-191
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