1887

Abstract

SUMMARY

Interaction of human polymorphonuclear leucocytes (PMNL) and influenza virus (IFV) was studied in . At 0°C, the viral particles were bound extensively to the surface of the PMNL membrane with a ratio of about 1000 virus particles to a single PMNL. The binding was sensitive to neuraminidase, suggesting attachment through sialo-compound receptors. At 37°C, the virus particles disappeared rapidly from the cell surface, about half of them being eluted and the remainder being endocytosed into the cytoplasmic vesicles. Immuno-gold electronmicroscopy suggests that the virus particles are ingested into phagosomal vesicles and lysed.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-28-3-191
1989-03-01
2024-12-06
Loading full text...

Full text loading...

/deliver/fulltext/jmm/28/3/medmicro-28-3-191.html?itemId=/content/journal/jmm/10.1099/00222615-28-3-191&mimeType=html&fmt=ahah

References

  1. Abramson J. S. 1986; Suppression of endocytosis in neutrophils by influenza A virus in vitro. Journal of Infectious Diseases 154:456–463
    [Google Scholar]
  2. Allen R. C., Mills E. L., McNitt T. R., Quie P. G. 1981; Role of myeloperoxidase and bacterial metabolism in chemiluminescence of granulocytes from patients with chronic granulomatous disease. Journal of Infectious Diseases 144:344–348
    [Google Scholar]
  3. Amano D., Kagosaki Y., Usui T., Yamamoto S., Hayaishi O. 1975; Inhibitory effects of superoxide dismutases and various other proteins on the nitroblue tetrazolium reduction by phagocytizing guinea pig polymorphonuclear leukocytes. Biochemical and Biophysical Research Communication 66:272–279
    [Google Scholar]
  4. Aminoff D. 1961; Methods for the quantitative estimation of N-acetylneuraminic acid and their application to hydrolysates of sialomucoids. Biochemical Journal 81:384–392
    [Google Scholar]
  5. Babior B. M. 1978; Oxygen-dependent microbial killing by phagocytes. New England Journal of Medicine 298:659–668
    [Google Scholar]
  6. Boyum A. 1968; Isolation of mononuclear cells and granulocytes from human blood. Scandinavian Journal of Clinical and Laboratory Investigation 21: Suppl 97 77–89
    [Google Scholar]
  7. Cardosa M. J., Gordon S., Hirsh S., Springer T. A., Porterfield J. S. 1986; Interaction of West Nile virus with primary murine macrophages: Role of cell activation and receptors for antibody and complement. Journal of Virology 57:952–959
    [Google Scholar]
  8. Domke-Opitz I., Straub P., Kirchner H. 1986; Effect of interferon on replication of herpes simplex virus types 1 and 2 in human macrophages. Journal of Virology 60:37–42
    [Google Scholar]
  9. Fischer J. J., Walker D. H. 1979; Invasive pulmonary aspergillosis associated with influenza. Journal of American Medical Association 241:1493–1494
    [Google Scholar]
  10. Fujisawa H., Tsuru S., Taniguchi M., Zinnaka Y., Nomoto K. 1987; Protective mechanisms against pulmonary infection with influenza virus. 1. Relative contribution of polymorphonuclear leukocytes and of alveolar macrophages to protection during the early phase of intranasal infection. Journal of General Virology 68:425–432
    [Google Scholar]
  11. Hirst G. K. 1942; Adsorption of influenza hemagglutinins and virus by red blood cells. Journal of Experimental Medicine 76:195–209
    [Google Scholar]
  12. Hirst G. K. 1943; Adsorption of influenza virus on cells of the respiratory tract. Journal of Experimental Medicine 78:99–109
    [Google Scholar]
  13. Inada T., Mims C. A. 1984; Mouse la antigens are receptors for lactate dehydrogenase virus. Nature 309:59–61
    [Google Scholar]
  14. Kiyotani K., Takei N., Matsuno Y. 1985; Depression of luminol-enhanced chemiluminescence of guinea pig polymorphonuclear leukocytes by influenza virus with special reference to neuraminidase. Hiroshima Journal of Medical Sciences 34:81–86
    [Google Scholar]
  15. Koenig S. 1986; Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233:1089–1093
    [Google Scholar]
  16. Mills E. L., Debets-Ossenkopp Y., Verbrugh H. A., Verhoef J. 1981; Initiation of the respiratory burst of human neutrophils by influenza virus. Infection and Immunity 32:1200–1205
    [Google Scholar]
  17. Mogensen S. C. 1979; Role of macrophages in natural resistance to virus infections. Microbiological Reviews 43:1–26
    [Google Scholar]
  18. Moore D. L., Mills E. L. 1987; Characterization of the chemotactic defect in polymorphonuclear leukocytes exposed to influenza virus in vitro. Blood 70:351–355
    [Google Scholar]
  19. Nagai T. 1985; Isolation of haemorrhagic fever with renal syndrome virus from leukocytes of rats and virus replication in cultures of rat and human macrophages. Journal of General Virology 66:1271–1278
    [Google Scholar]
  20. Rossiter P. B., Wardley R. C. 1985; The differential growth of virulent and avirulent strains of rinderpest virus in bovine lymphocytes and macrophages. Journal of General Virology 66:969–975
    [Google Scholar]
  21. Roth J. 1982; The protein A-gold (pAg) qualitative and quantitative approach for antigen localization on thin sections. In Bullock G. R., Petrusz P. (eds) Techniques in immunocytochemistry vol 1 Academic Press; London and New York: pp 107–133
    [Google Scholar]
  22. Rowson K. E. K., Mahy B. W. J. 1985; Lactate dehydrogenase-elevating virus. Journal of General Virology 66:2297–2312
    [Google Scholar]
  23. Ruutu P., Vaheri A., Kosunen T. U. 1977; Depression of human neutrophil motility by influenza virus in vitro. Scandinavian Journal of Immunology 6:897–906
    [Google Scholar]
  24. Schlesinger J. J., Ernst C., Weinstein L. 1976; Inhibition of human neutrophil chemotaxis by influenza virus. Lancet 1:650–651
    [Google Scholar]
  25. Suzuki K., Ota H., Sasagawa S., Sakatani T., Fujikura T. 1983; Assay method for myeloperoxidase in human polymorpho-nuclear leukocytes. Analytical Biochemistry 132:345–352
    [Google Scholar]
  26. Sweet C., Smith H. 1980; Pathogenicity of influenza virus. Microbiological Reviews 44:303–330
    [Google Scholar]
  27. Tobita K., Sugiura A., Enomoto C., Furuyama M. 1975; Plaque assay and primary isolation of influenza A viruses in an established line of canine kidney cells (MDCK) in the presence of trypsin. Medical Microbiology and Immunology 162:9–14
    [Google Scholar]
  28. Tsuru S., Fujisawa H., Taniguchi M., Zinnaka Y., Nomoto K. 1987; Mechanism of protection during the early phase of a generalized viral infection. II. Contribution of polymer-phonuclear leukocytes to protection against intravenous infection with influenza virus. Journal of General Virology 68:419–424
    [Google Scholar]
  29. Weissmann G., Zurier R. B., Spieler P. J., Goldstein I. M. 1971; Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles. Journal of Experimental Medicine 134: Suppl 149–165
    [Google Scholar]
  30. Weissmann G., Zurier R. B., Hoffstein S. 1973; Leukocytes as secretory organs of inflammation. Agents Actions 3:370–379
    [Google Scholar]
  31. Young L. S., Laforce M., Head J. J., Feeley B. S., Bennett J. V. 1972; A simultaneous outbreak of meningococcal and influenza infections. New England Journal of Medicine 287:5–9
    [Google Scholar]
/content/journal/jmm/10.1099/00222615-28-3-191
Loading
/content/journal/jmm/10.1099/00222615-28-3-191
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error