@article{mbs:/content/journal/jmm/10.1099/00222615-28-1-5, author = "Eke, P. I. and Laughon, B. E. and Rotimi, V. O.", title = "Cytotoxic activity of crude extracts of Bacteroides gingivalis", journal= "Journal of Medical Microbiology", year = "1989", volume = "28", number = "1", pages = "5-8", doi = "https://doi.org/10.1099/00222615-28-1-5", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-28-1-5", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "Summary The cytotoxic activities of culture supernates, crude cell extracts and cell-wall materials of Bacteroides gingivalis were investigated in vitro. Each component was cytotoxic to Vero cells and, to a lesser extent, Wi 38 cells. The cytotoxic agents had similar effects on the cell lines to butyric acid, propionic acid and a partially-purified trypsin-like protein extracted from a clinical isolate of B. gingivalis; the effects were eliminated by heat. Cytotoxic materials obtained from young cultures were more susceptible to heat than those from older cultures. The heat-labile substance inside and outside the bacterial cell in young cultures of B. gingivalis may contribute to its overall cytotoxic activity.", }