The cytotoxic activities of culture supernates, crude cell extracts and cell-wall materials of were investigated Each component was cytotoxic to Vero cells and, to a lesser extent, Wi 38 cells. The cytotoxic agents had similar effects on the cell lines to butyric acid, propionic acid and a partially-purified trypsin-like protein extracted from a clinical isolate of ; the effects were eliminated by heat. Cytotoxic materials obtained from young cultures were more susceptible to heat than those from older cultures. The heat-labile substance inside and outside the bacterial cell in young cultures of may contribute to its overall cytotoxic activity.


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