Molecular variants of the serotype-specific plasmid (SSP) of (pSLT) were recognised in clinical and veterinary isolates by restriction enzyme fingerprinting. Three had undergone minor DNA rearrangements, whereas two had acquired resistance determinants to a wide range of antimicrobial agents including gentamicin, trimethoprim, tetracycline, streptomycin, ampicillin (Ap) and kanamycin (Km). One of the latter was the result of co-integrate formation with an IncX, conjugative R-plasmid that specified ApKm resistance. The co-integrate plasmid (pOG669) was incompatible with, and displaced, pSLT and its molecular variants. The restriction fingerprints of SSPs of and were compared with pSLT. All were related at the 35% level on the basis of a Dice coefficient of similarity. The SSPs of and were incompatible with the co-integrate plasmid pOG669. Whereas in this resulted from incompatibility with the pSLT component (the SSP was compatible with the IncX component), the converse was found with


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