Liver xanthine oxidase (XOD) and superoxide dismutase (SOD) activities were compared in mice during Salmonella typhimurium and Pseudomonas aeruginosa infections. We observed that XOD activity rose but SOD activity fell for the first 11 days after infection with smooth type S. typhimurium, coinciding with the period of bacterial growth in the liver. Rough type S. typhimurium did not establish an infection and mice inoculated with this strain showed no variation in enzyme activities. P. aeruginosa infection was mild but stimulated both XOD and SOD activities.
AffonsoO. R.,
MouraC. V. A.,
CavallariV.,
MitidieriE.1981; Serum and liver xanthine oxidase activity in tumor bearing rats and mice. Anais Da Academia Brasileira De Ciencias 53:617–620
ChambersD. E.,
ParksD. A.,
PattersonG.,
RoyR.,
McCordJ. M.,
YoshidaS.,
ParmleyL. F.,
DowneyJ. M.1985; Xanthine oxidase as a source of free radical damage in myocardial ischemia. Journal of Molecular and Cellular Cardiology 17:145–152
DeloriaL.,
AbbottV.,
GooderhamN.,
ManneringG. J.1985; Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: genetic difference in the response of mice. Biochemical and Biophysical Research Communications 131:109–114
GhezziP.,
BianchiM.,
MantovaniA.,
SpreaficoF.,
SalmonaM.1984; Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers. Biochemical and Biophysical Research Communications 119:144–149
JaraschE. D.,
GrundC.,
BruderG.,
HeidH. W.,
KeenanT. W.,
FrankeW. W.1981; Localization of xanthine oxidase in mammary-gland epithelium and capillary endothelium. Cell 25:67–82
KoizumiA.,
WalfordR. L.,
ImamuraT.1986; Treatment with poly I.C. enhances lipid peroxidation and the activity of xanthine oxidase, and decreases hepatic P-450 content and activities in mice and rats. Biochemical and Biophysical Research Communications 134:632–637
KulkarniA. B.,
VedH. S.,
RamarkrishmanP.,
PradhanV. R.,
RenapurkarD. M.,
SharmaK. D.1981; Studies on superoxide dismutase and catalase in different tissues of rat infected with Plasmodium berghei. Bulletin Haffkine Institute 9:29–33
LeuthauserS. W. C.,
OberleyL. W.,
OberleyT. D.,
LovenD. P.1984; Lowered superoxide dismutase activity in distant organs of tumor-bearing mice. Journal of the National Cancer Institute 72:1065–1074
TubaroE.,
LottiB.,
CavalloG.,
CroceC.,
BorelliG.1980; Liver xanthine oxidase increase in mice in three pathological models. A possible defence mechanism. Biochemical Pharmacology 29:1939–1943
TubaroE.,
LottiB.,
SantiangeliC.,
CavalloG.1980; Xanthine oxidase increase in polymorphonuclear leukocytes and macrophages in mice in three pathological situations. Biochemical Pharmacology 29:1945–1948