Isolates of Haemophilus influenzae obtained sequentially over a period of 2 years from 62 patients with cystic fibrosis were biotyped. Rapid changes were seen from month to month in biotypes isolated from the respiratory tract and only a few of the patients harboured the same biotype for several months. Up to four biotypes were present simultaneously, whereas even two different biotypes were found in only one of a series of 148 patients with respiratory infections but not cystic fibrosis. Colony morphology was no guide to biotype, since the same biotype may show different colony appearances on the same plate and different biotypes may show identical colony forms.
DeMariaT. F.,
LimD. J.,
BamishanJ.,
AyersL. W.,
BirckH. G.1984; Biotypes of serologically non-typable Haemophilus influenzae isolated from the middle ears and nasopharynges of patients with otitis media with effusion. Journal of Clinical Microbiology 20:1102–1104
GranatoP. A.,
JurekE. A.,
WeinerL. B.1983; Biotypes of Haemophilus influenzae: relationship to clinical source of isolation, serotype and antibiotic susceptibility. American Journal of Clinical Pathology 79:73–77
KammeC.1980; Biotypes of capsulated and non-capsulated Haemophilus influenzae. Correlation between biotypes and beta-lactamase production. Acta Pathologica et Microbiolo-gica Scandinavica, Section B 88:261–264
TsaiW. C.,
WuJ. J.1979; Serotypes and biotypes and antibiotic susceptibility of Haemophilus influenzae encountered in a clinical laboratory in Taiwan. Chinese Journal of Microbiology 12:140–148
WatsonK. C.,
KerrE. J. C.,
HinksC. A.1985; The distribution of biotypes of Haemophilus influenzae and H. parainfluenzae in patients with cystic fibrosis. Journal of Clinical Pathology 38:750–753