Role of murine macrophages and complement in experimental campylobacter infection Free

Abstract

SUMMARY

The roles of macrophages and the complement system as potential host defence mechanisms in mice against campylobacter infection were studied , by depleting the murine serum-complement or the phagocytic cells. Macrophage-depletion was performed by intraperitoneal (i.p.) injection of silica dust, Liquoid or dextran sulphate. During 5 days after infection, such mice showed a significant increase in mortality, compared with controls. In contrast, mice that were previously decomplemented by i.p. injection of Cobra Venom Factor showed no significant increase in mortality. The results with combined macrophage depletion and decomplementation did not differ from those with macrophage depletion alone. These experiments suggest that macrophages seem to be more important than complement in the defence of mice against experimental campylobacter infection.

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1988-05-01
2024-03-29
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References

  1. Allison A. C., Harington J. S., Birbeck M. 1966; An examination of the cytotoxic effects of silica on macrophages. Journal of Experimental Medicine 124:141–154
    [Google Scholar]
  2. Banfi E., Cinco M., Zabucchi F. 1986; Phagocytosis of Campylobacter jejuni and C. coli by peritoneal macrophages. Journal of General Microbiology 132:2409–2412
    [Google Scholar]
  3. Bitter-Suermann D., Dierich M., Konig W., Hadding U. 1972; Bypass-activation of the complement system starting with C3. Immunology 23:267–281
    [Google Scholar]
  4. Blaser M. J., Duncan D. J., Warren G. H., Wang W. L. 1983; Experimental Campylobacter jejuni infection of adult mice. Infection and Immunity 39:908–916
    [Google Scholar]
  5. Blaser M. J., Smith P. F., Kohler P. F. 1985; Susceptibility of Campylobacter isolates to the bactericidal activity of human serum. Journal of Infectious Diseases 151:227–235
    [Google Scholar]
  6. Bloksma N., de Reuver M. J., Willers J. M. 1980; Influence on macrophage functions as a possible basis of immunomodifications by polyanions. Annales d’lmmunologie 131D:255–265
    [Google Scholar]
  7. Bottger E. C., Hoffman T., Metzger S., Hadding U., Suermann D. 1986; The role and mechanism of Cobra Venom Factor-induced suppression of the humoral immune response in guinea pigs. Journal of Immunology 137:1280–1285
    [Google Scholar]
  8. DuBuy H. 1975; Effect of silica on virus infections in mice and mouse tissue culture. Infection and Immunity 11:996–1002
    [Google Scholar]
  9. Cochrane C. G., Eberhard H. J., Aikin B. S. 1970; Depletion of plasma complement in vivo by a protein from Cobra Venom: its effect on various immunological reactions. Journal of Immunology 105:55–69
    [Google Scholar]
  10. Duffy M. C., Benson J. B., Rubin S. J. 1980; Mucosal invasion in Campylobacter enteritis. American Journal of Clinical Pathology 73:706–708
    [Google Scholar]
  11. Fox J. G. 1982; Campylobacteriosis—a “new” disease in laboratory animals. Laboratory Animal Science 32:625–637
    [Google Scholar]
  12. Humphrey C. D., Montag D. M., Pittman F. E. 1986; Morphologic observations of experimental Campylobacter jejuni infection in the hamster intestinal tract. American Journal ofPathology 122:152–159
    [Google Scholar]
  13. Kazmi S. U., Roberson B. S., Stern N. J. 1984; Animal passed, virulence-enhanced Campylobacter jejuni causes enteritis in neonatal mice. Current Microbiology 11:159–164
    [Google Scholar]
  14. Kiehlbauch J. A., Albach R. A., Baum L. L., Chang K. P. 1985; Phagocytosis of Campylobacter jejuni and its intracellular survival in mononuclear phagocytes. Infection and Immunity 48:446–451
    [Google Scholar]
  15. Laurell C. B. 1972; Electroimmuno assay. Scandinavian Journal of Clinical and Laboratory Investigation 29: Suppl 12421–23
    [Google Scholar]
  16. Loos M. 1983; Biosynthesis of the collagen-like Clq molecule and its receptor functions for Fc and polyanionic molecules in macrophages. Current Topics in Microbiology and Immunology 102:1–56
    [Google Scholar]
  17. Madge D. S. 1980; Campylobacter enteritis in young mice. Digestion 20:389–394
    [Google Scholar]
  18. McCardell B. A., Madden J. M., Stanfield J. T. 1986; A mouse model for the measurement of virulence of species of Campylobacter. Journal of Infectious Diseases 153:177
    [Google Scholar]
  19. Ng F. K. P., Wardlaw A. C., Tull D. E. S. 1980; Enhancement of the lethal effect of Campylobacter fetus ssp.jejuni in seven-day old mice by ferric ammonium citrate. Society for General Microbiology Quarterly 8:12
    [Google Scholar]
  20. Perez-Perez G. I., Hopkins J. A., Blaser M. J. 1986; Lipopolysac-charide structure in Enterobacteriaceae, Pseudomonas aeruginosa and Vibrio cholerae are immunologically related to Campylobacter spp. Infection and Immunity 51:204–208
    [Google Scholar]
  21. Schultz D. R., Arnold P. I. 1977; Venom of the ant Pseudomyrmex sp.: further characterisation of two factors that affect human complement proteins. Journal of Immunology 119:1690–1699
    [Google Scholar]
  22. Skirrow M. B. 1977; Campylobacter enteritis: a “new” disease. British Medical Journal 2:9–11
    [Google Scholar]
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