1887

Abstract

Summary

A strain of resistant to rifampicin (RMP) failed to infect normal mice when injected into the foot pads (FP) at a dose of 10 or 100 bacilli/FP, although it could be maintained by serial passage in mice by the use of inocula of 10 bacilli/FP; normal mice can be infected by RMP-sensitive . at a dose of 10 bacilli/FP. By contrast, nude (athymic) mice could be infected with an inoculum of 10 bacilli/FP of the RMP-resistant strain. It is suggested that the strain concerned possessed reduced virulence for normal mice, and the implications of this for the probability of occurrence of human disease caused by RMP-resistant strains of are discussed.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-25-1-13
1988-01-01
2024-04-24
Loading full text...

Full text loading...

/deliver/fulltext/jmm/25/1/medmicro-25-1-13.html?itemId=/content/journal/jmm/10.1099/00222615-25-1-13&mimeType=html&fmt=ahah

References

  1. Colston M J, Hilson G R F. 1976; Growth of Mycobacterium marinum and Mycobacterium leprae in congenitally athymic (nude) mice. IRCS Medical Science 4:186
    [Google Scholar]
  2. Daddi G, Lucchesi M, Mancini P, Termine A. 1971; Virulence attenuation and other biological modifications in multiple drug-resistant tubercle mycobacteria. Bolletino Istituto Sieroterapico Milanese 50:353–361
    [Google Scholar]
  3. Guelpa-Lauras C, Grosset J H, Constant-Desportes M, Brucker G. 1984; Nine cases of rifampin-resistant leprosy. International Journal of Leprosy 52:101–102
    [Google Scholar]
  4. Jacobson R R, Hastings R C. 1976; Rifampin-resistant leprosy. Lancet 2:1304–1305
    [Google Scholar]
  5. Kopanoff D E, Kilburn J O, Glassroth J L, Snider D E, Farer L S, Good R C. 1978; A continuing survey of tuberculosis primary drug resistance in the United States: March 1975 to November 1977. A United States Public Health Service Cooperative Study. American Review of Respiratory Disease 118:835–842
    [Google Scholar]
  6. Lancaster R D. 1985; The development and use of the nude mouse as a model of lepromatous leprosy. PhD thesis University of London;
    [Google Scholar]
  7. Lancaster R D, Hilson G R F, McDougall A C, Colston M J. 1983; Mycobacterium leprae infection in nude mice : bacteri- ological and histological responses to primary infection and large inocula. Infection and Immunity 39:865–872
    [Google Scholar]
  8. Meissner G. 1964; The bacteriology of the tubercle bacillus. Barry V C. Chemotherapy of tuberculosis Butterworths; London:80–89
    [Google Scholar]
  9. Moorman D R, Mandell G L. 1981; Characteristics of rifampin-resistant variants obtained from clinical isolates of Staphy-lococcus aureus. Antimicrobial Agents and Chemotherapy 20:709–713
    [Google Scholar]
  10. Shepard C C. 1960; The experimental disease that follows the injection of human leprosy bacilli into foot-pads of mice. Journal of Experimental Medicine 112:445–454
    [Google Scholar]
  11. Shepard C C, McRae D H. 1965; Mycobacterium leprae in mice: minimal infectious dose, relationship between staining quality and infectivity, and effect of cortisone. Journal of Bacteriology 89:365–372
    [Google Scholar]
  12. Shepard C C, McRae D H. 1968; A method for counting acid-fast bacteria. International Journal of Leprosy 36:78–82
    [Google Scholar]
  13. Steiner P, Rao M, Victoria M S, Hunt J, Steiner M. 1983; A continuing study of primary drug-resistant tuberculosis among children observed at the Kings County Hospital Medical Center between the years 1961 and 1980. American Review of Respiratory Disease 128:425–428
    [Google Scholar]
  14. Waters M F R, Laing A B G, Rees R J W. 1978; Proven primary dapsone resistance in leprosy – a case report. Leprosy Review 49:127–130
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-25-1-13
Loading
/content/journal/jmm/10.1099/00222615-25-1-13
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error